The Use of Systemic Inflammatory Markers From Routine Blood Tests in Predicting Preeclampsia and the Impact of Age on Marker Levels

Our study aimed to investigate the relationship between preeclampsia (PE) and blood levels of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) in the first trimester of pregnancy. In addition to examining the potential correlation between these inflammatory markers and PE, we aimed to compare the levels based on age to determine whether there are potential age-related differences in marker levels. Over a six-month period, we reviewed the complete blood count (CBC) analysis results of 126 subjects, where 63 patients had a documented history of PE and 63 were healthy pregnant females. We found that age had no statistically significant effect on NLR, MLR, or SII levels, but there was a statistically significant difference in PLR levels between the 18-25 and 26-35 age groups. The study also revealed that the MLR and PLR in the 18-25 age group of preeclampsia patients were statistically significantly lower than those of healthy patients, whereas the PLR and SII in the 26-35 age group of preeclampsia patients were statistically significantly higher than those of healthy patients. The results suggest that systemic inflammatory response (SIR) markers may be able to predict the development of preeclampsia. The study also emphasized the importance of taking age into account, specifically the 18-25 and 26-35 age groups, when assessing the risk of preeclampsia. Further research is needed however to corroborate existing findings and determine the importance of the examined inflammatory markers in the diagnosis of PE.