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The A allele of the rs759853 single nucleotide polymorphism in the AKR1B1 gene confers risk for diabetic kidney disease in patients with type 2 diabetes from a Brazilian population

OBJECTIVE: The AKR1B1 gene encodes an enzyme that catalyzes the reduction of glucose into sorbitol. Chronic hyperglycemia in patients with diabetes mellitus (DM) leads to increased AKR1B1 affinity for glucose and, consequently, sorbitol accumulation. Elevated sorbitol increases oxidative stress, whi...

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Detalles Bibliográficos
Autores principales:	Dieter, Cristine, Lemos, Natália Emerim, Corrêa, Nathalia Rodrigues de Faria, Pellenz, Felipe Mateus, Canani, Luís Henrique, Crispim, Daisy, Bauer, Andrea Carla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Endocrinologia e Metabologia 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991038/ https://www.ncbi.nlm.nih.gov/pubmed/35029856 http://dx.doi.org/10.20945/2359-3997000000432

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