Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity

AIMS: Calcific aortic valve disease (CAVD) is the most common valve disease, which consists of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as a novel key player in the pathophysiology of CAVD, and its role in the transformation of...

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Detalles Bibliográficos
Autores principales: Iqbal, Farwah, Schlotter, Florian, Becker-Greene, Dakota, Lupieri, Adrien, Goettsch, Claudia, Hutcheson, Joshua D, Rogers, Maximillian A, Itoh, Shinsuke, Halu, Arda, Lee, Lang Ho, Blaser, Mark C, Mlynarchik, Andrew K, Hagita, Sumihiko, Kuraoka, Shiori, Chen, Hao Yu, Engert, James C, Passos, Livia S A, Jha, Prabhash K, Osborn, Eric A, Jaffer, Farouc A, Body, Simon C, Robson, Simon C, Thanassoulis, George, Aikawa, Masanori, Singh, Sasha A, Sonawane, Abhijeet R, Aikawa, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991042/
https://www.ncbi.nlm.nih.gov/pubmed/36660854
http://dx.doi.org/10.1093/eurheartj/ehac818

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