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A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
Ca(2+) release-activated Ca(2+) (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca(2+) sensor. A hallmark of CRAC channels is fast Ca(2+)-dependent inactivation (CDI) which provides negative feedback to limit Ca(2...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991058/ https://www.ncbi.nlm.nih.gov/pubmed/36806330 http://dx.doi.org/10.7554/eLife.82281 |