Cargando…

A70 FECAL-ADHERENT MUCUS IS A NON-INVASIVE SOURCE OF PRIMARY HUMAN MUC2 FOR STRUCTURAL AND FUNCTIONAL CHARACTERIZATION IN HEALTH AND DISEASE

BACKGROUND: The gel-forming O-glycoprotein Mucin-2 (MUC2) is a key mediator of host-microbe homeostasis in part by forming a barrier to segregate inflammatory microbes from distal colon tissues. While animal models have provided insights into how Muc2 functions, relatively few studies have explored...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fancy, N, Melvin, M, N, N, Kazemian, N, D’Aloisio, L, Davidson-Hunt, S, Chadee, K, Pakpour, S, Ghosh, S, Gibson, D, Zandberg, W, Bergstrom, K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Poster Presentations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991287/ http://dx.doi.org/10.1093/jcag/gwac036.070

Ejemplares similares

A230 A MISSENSE MUTATION IN GOBLET CELL PROTEIN FCGBP ALTERS THE GLYCOMIC PROFILE AND FUNCTION OF THE COLONIC MUCUS BARRIER
por: Gorman, H, et al.
Publicado: (2023)

A21 ROLE OF SIALIC ACID O-ACETYLATION IN MAINTAINING MUCUS INTEGRITY AND HOMEOSTASIS OF THE COLONIC MUCOSA
por: Jafaripour, S, et al.
Publicado: (2023)

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B
por: Bonser, Luke R., et al.
Publicado: (2017)

Fecal Microbiota Transplantation during and Post-COVID-19 Pandemic
por: Kazemian, Negin, et al.
Publicado: (2021)

Muc5b Is the Major Polymeric Mucin in Mucus from Thoroughbred Horses With and Without Airway Mucus Accumulation
por: Rousseau, Karine, et al.
Publicado: (2011)

Muc5b Contributes to Mucus Abnormality in Rat Models of Cystic Fibrosis
por: Keith, Johnathan D., et al.
Publicado: (2022)

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease
por: Livraghi-Butrico, Alessandra, et al.
Publicado: (2016)

Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16
por: Gunn, Bronwyn, et al.
Publicado: (2016)

A165 FCGBP IN THE COLON IS SPATIALLY DEPENDENT ON MUC2 EXPRESSION AND IS DEGRADED IN DEXTRAN SULFATE SODIUM-INDUCED COLITIS
por: Kim, A, et al.
Publicado: (2023)

Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2
por: Cobo, E R, et al.
Publicado: (2015)

Age-Related Mucus Barrier Dysfunction in Mice Is Related to the Changes in Muc2 Mucin in the Colon
por: Sang, Xueqin, et al.
Publicado: (2023)

A198 COLONIC MUC2 MUCIN IS STABILIZED BY FCGBP TO RESIST SALMONELLA TYPHIMURIUM INVASION IN GOBLET CELLS
por: Gorman, H, et al.
Publicado: (2022)

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa
por: Bergstrom, Kirk S. B., et al.
Publicado: (2010)

A43 HIGH MUC2 MUCIN BIOSYNTHESIS BY GOBLET CELLS UNDER METABOLIC STRESS PRODUCE ELEVATED LEVELS OF PRO-INFLAMMATORY CYTOKINES
por: Kim, A, et al.
Publicado: (2022)

A273 INCREASING THE REPRESENTATION OF INDIANS IN MICROBIOME RESEARCH: HOW DOES THEIR GUT MICROBIOME DIFFER?
por: D'Aloisio, L D, et al.
Publicado: (2023)

Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection
por: Birchenough, George M.H., et al.
Publicado: (2023)

ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells
por: Du, Xizi, et al.
Publicado: (2022)

Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production
por: Kajiwara-Kubota, Mariko, et al.
Publicado: (2023)

Acute infection with Brachyspira hyodysenteriae affects mucin expression, glycosylation, and fecal MUC5AC
por: Lin, Susanne Je-Han, et al.
Publicado: (2023)

Immunological characterization of endocervical mucus in normal and neoplastic tissue.
por: Cauchi, M. N., et al.
Publicado: (1981)

Tumor Necrosis Factor-α and Muc2 Mucin Play Major Roles in Disease Onset and Progression in Dextran Sodium Sulphate-Induced Colitis
por: Dharmani, Poonam, et al.
Publicado: (2011)

Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica
por: Leon-Coria, Aralia, et al.
Publicado: (2018)

Altering Mucus Rheology to “Solidify” Human Mucus at the Nanoscale
por: Lai, Samuel K., et al.
Publicado: (2009)

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
por: Cornick, Steve, et al.
Publicado: (2019)

Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation
por: Wang, Xiaoyun, et al.
Publicado: (2017)

Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury
por: Leon-Coria, Aralia, et al.
Publicado: (2020)

Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro
por: Chorley, Brian N, et al.
Publicado: (2006)

Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
por: Kozik, Ariangela J., et al.
Publicado: (2019)

IgGFc-binding protein and MUC2 mucin produced by colonic goblet-like cells spatially interact non-covalently and regulate wound healing
por: Gorman, Hayley, et al.
Publicado: (2023)

The trans-kingdom battle between donor and recipient gut microbiome influences fecal microbiota transplantation outcome
por: Kazemian, Negin, et al.
Publicado: (2020)

Author Correction: Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production
por: Kajiwara-Kubota, Mariko, et al.
Publicado: (2023)

Mucus
por: Cutler, Andrew S.
Publicado: (1868)

Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin
por: Bafna, S, et al.
Publicado: (2009)

Author Correction: The trans-kingdom battle between donor and recipient gut microbiome influences fecal microbiota transplantation outcome
por: Kazemian, Negin, et al.
Publicado: (2021)

Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis
por: Yamamoto-Furusho, Jesús K., et al.
Publicado: (2015)

Identification of Mucus-Associated Molecular Subtypes of Chronic Obstructive Pulmonary Disease: A Latent Profile Analysis Based on MUC5B-Associated Genes
por: Hu, Yuanlong, et al.
Publicado: (2021)

MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance
por: Betge, Johannes, et al.
Publicado: (2016)

AGR2, an Endoplasmic Reticulum Protein, Is Secreted into the Gastrointestinal Mucus
por: Bergström, Joakim H., et al.
Publicado: (2014)

Across the mucus
por: Taglialegna, Agustina
Publicado: (2022)

Neuraminidase B controls neuraminidase A-dependent mucus production and evasion
por: Hammond, Alexandria J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nr6thhpji12ptirjvh2bbgeu6l