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IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991911/ https://www.ncbi.nlm.nih.gov/pubmed/36575242 http://dx.doi.org/10.1038/s41375-022-01805-9 |
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| author | Yu, Jifeng Li, Song Chen, Dianze Liu, Dandan Guo, Huiqin Yang, Chunmei Zhang, Wei Zhang, Li Zhao, Gui Tu, Xiaoping Peng, Liang Liu, Sijin Bai, Xing Song, Yongping Jiang, Zhongxing Zhang, Ruliang Tian, Wenzhi |
| author_facet | Yu, Jifeng Li, Song Chen, Dianze Liu, Dandan Guo, Huiqin Yang, Chunmei Zhang, Wei Zhang, Li Zhao, Gui Tu, Xiaoping Peng, Liang Liu, Sijin Bai, Xing Song, Yongping Jiang, Zhongxing Zhang, Ruliang Tian, Wenzhi |
| author_sort | Yu, Jifeng |
| collection | PubMed |
| description | |
| format | Online Article Text |
| id | pubmed-9991911 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99919112023-03-09 IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells Yu, Jifeng Li, Song Chen, Dianze Liu, Dandan Guo, Huiqin Yang, Chunmei Zhang, Wei Zhang, Li Zhao, Gui Tu, Xiaoping Peng, Liang Liu, Sijin Bai, Xing Song, Yongping Jiang, Zhongxing Zhang, Ruliang Tian, Wenzhi Leukemia Letter Nature Publishing Group UK 2022-12-27 2023 /pmc/articles/PMC9991911/ /pubmed/36575242 http://dx.doi.org/10.1038/s41375-022-01805-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Letter Yu, Jifeng Li, Song Chen, Dianze Liu, Dandan Guo, Huiqin Yang, Chunmei Zhang, Wei Zhang, Li Zhao, Gui Tu, Xiaoping Peng, Liang Liu, Sijin Bai, Xing Song, Yongping Jiang, Zhongxing Zhang, Ruliang Tian, Wenzhi IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells |
| title | IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells |
| title_full | IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells |
| title_fullStr | IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells |
| title_full_unstemmed | IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells |
| title_short | IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells |
| title_sort | imm0306, a fusion protein of cd20 mab with the cd47 binding domain of sirpα, exerts excellent cancer killing efficacy by activating both macrophages and nk cells via blockade of cd47-sirpα interaction and fcɣr engagement by simultaneously binding to cd47 and cd20 of b cells |
| topic | Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991911/ https://www.ncbi.nlm.nih.gov/pubmed/36575242 http://dx.doi.org/10.1038/s41375-022-01805-9 |
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