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A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans
Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by de...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991917/ https://www.ncbi.nlm.nih.gov/pubmed/36804647 http://dx.doi.org/10.1038/s41593-023-01260-4 |
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author | Topalovic, Uros Barclay, Sam Ling, Chenkai Alzuhair, Ahmed Yu, Wenhao Hokhikyan, Vahagn Chandrakumar, Hariprasad Rozgic, Dejan Jiang, Wenlong Basir-Kazeruni, Sina Maoz, Sabrina L. Inman, Cory S. Stangl, Matthias Gill, Jay Bari, Ausaf Fallah, Aria Eliashiv, Dawn Pouratian, Nader Fried, Itzhak Suthana, Nanthia Markovic, Dejan |
author_facet | Topalovic, Uros Barclay, Sam Ling, Chenkai Alzuhair, Ahmed Yu, Wenhao Hokhikyan, Vahagn Chandrakumar, Hariprasad Rozgic, Dejan Jiang, Wenlong Basir-Kazeruni, Sina Maoz, Sabrina L. Inman, Cory S. Stangl, Matthias Gill, Jay Bari, Ausaf Fallah, Aria Eliashiv, Dawn Pouratian, Nader Fried, Itzhak Suthana, Nanthia Markovic, Dejan |
author_sort | Topalovic, Uros |
collection | PubMed |
description | Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species. |
format | Online Article Text |
id | pubmed-9991917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-99919172023-03-09 A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans Topalovic, Uros Barclay, Sam Ling, Chenkai Alzuhair, Ahmed Yu, Wenhao Hokhikyan, Vahagn Chandrakumar, Hariprasad Rozgic, Dejan Jiang, Wenlong Basir-Kazeruni, Sina Maoz, Sabrina L. Inman, Cory S. Stangl, Matthias Gill, Jay Bari, Ausaf Fallah, Aria Eliashiv, Dawn Pouratian, Nader Fried, Itzhak Suthana, Nanthia Markovic, Dejan Nat Neurosci Technical Report Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species. Nature Publishing Group US 2023-02-20 2023 /pmc/articles/PMC9991917/ /pubmed/36804647 http://dx.doi.org/10.1038/s41593-023-01260-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Technical Report Topalovic, Uros Barclay, Sam Ling, Chenkai Alzuhair, Ahmed Yu, Wenhao Hokhikyan, Vahagn Chandrakumar, Hariprasad Rozgic, Dejan Jiang, Wenlong Basir-Kazeruni, Sina Maoz, Sabrina L. Inman, Cory S. Stangl, Matthias Gill, Jay Bari, Ausaf Fallah, Aria Eliashiv, Dawn Pouratian, Nader Fried, Itzhak Suthana, Nanthia Markovic, Dejan A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans |
title | A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans |
title_full | A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans |
title_fullStr | A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans |
title_full_unstemmed | A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans |
title_short | A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans |
title_sort | wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans |
topic | Technical Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991917/ https://www.ncbi.nlm.nih.gov/pubmed/36804647 http://dx.doi.org/10.1038/s41593-023-01260-4 |
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