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The impact of brain lesions on health-related quality of life in patients with WHO CNS grade 3 or 4 glioma: a lesion-function and resting-state fMRI analysis
PURPOSE: In glioma patients, tumor development and multimodality therapy are associated with changes in health-related quality of life (HRQoL). It is largely unknown how different types and locations of tumor- and treatment-related brain lesions, as well as their relationship to white matter tracts...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992025/ https://www.ncbi.nlm.nih.gov/pubmed/36750534 http://dx.doi.org/10.1007/s11060-023-04254-1 |
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author | Heinzel, Alexander Mottaghy, Felix M. Filss, Christian Stoffels, Gabriele Lohmann, Philipp Friedrich, Michel Shah, Nadim J. Caspers, Svenja Lucas, Carolin Weiss Ruge, Maximilian I. Galldiks, Norbert Fink, Gereon R. Langen, Karl-Josef Kocher, Martin |
author_facet | Heinzel, Alexander Mottaghy, Felix M. Filss, Christian Stoffels, Gabriele Lohmann, Philipp Friedrich, Michel Shah, Nadim J. Caspers, Svenja Lucas, Carolin Weiss Ruge, Maximilian I. Galldiks, Norbert Fink, Gereon R. Langen, Karl-Josef Kocher, Martin |
author_sort | Heinzel, Alexander |
collection | PubMed |
description | PURPOSE: In glioma patients, tumor development and multimodality therapy are associated with changes in health-related quality of life (HRQoL). It is largely unknown how different types and locations of tumor- and treatment-related brain lesions, as well as their relationship to white matter tracts and functional brain networks, affect HRQoL. METHODS: In 121 patients with pretreated gliomas of WHO CNS grades 3 or 4, structural MRI, O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) PET, resting-state functional MRI (rs-fMRI) and self-reported HRQoL questionnaires (EORTC QLQ-C30/BN20) were obtained. Resection cavities, T1-enhancing lesions, T2/FLAIR hyperintensities, and lesions with pathologically increased FET uptake were delineated. Effects of tumor lateralization, involvement of white matter tracts or resting-state network nodes by different types of lesions and within-network rs-fMRI connectivity were analyzed in terms of their interaction with HRQoL scores. RESULTS: Right hemisphere gliomas were associated with significantly less favorable outcomes in physical, role, emotional and social functioning, compared with left-sided tumors. Most functional HRQoL scores correlated significantly with right-sided white-matter tracts involvement by T2/FLAIR hyperintensities and with loss of within-network functional connectivity of right-sided nodes. Tumors of the left hemisphere caused significantly more communication deficits. CONCLUSION: In pretreated high-grade gliomas, right hemisphere lesions are associated with reduced HRQoL scores in most functional domains except communication ability, compared to tumors of the left hemisphere. These relationships are mainly observed for T2/FLAIR lesions involving structural and functional networks in the right hemisphere. The data suggest that sparing the right hemisphere from treatment-related tissue damage may improve HRQoL in glioma patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11060-023-04254-1. |
format | Online Article Text |
id | pubmed-9992025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-99920252023-03-09 The impact of brain lesions on health-related quality of life in patients with WHO CNS grade 3 or 4 glioma: a lesion-function and resting-state fMRI analysis Heinzel, Alexander Mottaghy, Felix M. Filss, Christian Stoffels, Gabriele Lohmann, Philipp Friedrich, Michel Shah, Nadim J. Caspers, Svenja Lucas, Carolin Weiss Ruge, Maximilian I. Galldiks, Norbert Fink, Gereon R. Langen, Karl-Josef Kocher, Martin J Neurooncol Case Study PURPOSE: In glioma patients, tumor development and multimodality therapy are associated with changes in health-related quality of life (HRQoL). It is largely unknown how different types and locations of tumor- and treatment-related brain lesions, as well as their relationship to white matter tracts and functional brain networks, affect HRQoL. METHODS: In 121 patients with pretreated gliomas of WHO CNS grades 3 or 4, structural MRI, O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) PET, resting-state functional MRI (rs-fMRI) and self-reported HRQoL questionnaires (EORTC QLQ-C30/BN20) were obtained. Resection cavities, T1-enhancing lesions, T2/FLAIR hyperintensities, and lesions with pathologically increased FET uptake were delineated. Effects of tumor lateralization, involvement of white matter tracts or resting-state network nodes by different types of lesions and within-network rs-fMRI connectivity were analyzed in terms of their interaction with HRQoL scores. RESULTS: Right hemisphere gliomas were associated with significantly less favorable outcomes in physical, role, emotional and social functioning, compared with left-sided tumors. Most functional HRQoL scores correlated significantly with right-sided white-matter tracts involvement by T2/FLAIR hyperintensities and with loss of within-network functional connectivity of right-sided nodes. Tumors of the left hemisphere caused significantly more communication deficits. CONCLUSION: In pretreated high-grade gliomas, right hemisphere lesions are associated with reduced HRQoL scores in most functional domains except communication ability, compared to tumors of the left hemisphere. These relationships are mainly observed for T2/FLAIR lesions involving structural and functional networks in the right hemisphere. The data suggest that sparing the right hemisphere from treatment-related tissue damage may improve HRQoL in glioma patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11060-023-04254-1. Springer US 2023-02-07 2023 /pmc/articles/PMC9992025/ /pubmed/36750534 http://dx.doi.org/10.1007/s11060-023-04254-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Case Study Heinzel, Alexander Mottaghy, Felix M. Filss, Christian Stoffels, Gabriele Lohmann, Philipp Friedrich, Michel Shah, Nadim J. Caspers, Svenja Lucas, Carolin Weiss Ruge, Maximilian I. Galldiks, Norbert Fink, Gereon R. Langen, Karl-Josef Kocher, Martin The impact of brain lesions on health-related quality of life in patients with WHO CNS grade 3 or 4 glioma: a lesion-function and resting-state fMRI analysis |
title | The impact of brain lesions on health-related quality of life in patients with WHO CNS grade 3 or 4 glioma: a lesion-function and resting-state fMRI analysis |
title_full | The impact of brain lesions on health-related quality of life in patients with WHO CNS grade 3 or 4 glioma: a lesion-function and resting-state fMRI analysis |
title_fullStr | The impact of brain lesions on health-related quality of life in patients with WHO CNS grade 3 or 4 glioma: a lesion-function and resting-state fMRI analysis |
title_full_unstemmed | The impact of brain lesions on health-related quality of life in patients with WHO CNS grade 3 or 4 glioma: a lesion-function and resting-state fMRI analysis |
title_short | The impact of brain lesions on health-related quality of life in patients with WHO CNS grade 3 or 4 glioma: a lesion-function and resting-state fMRI analysis |
title_sort | impact of brain lesions on health-related quality of life in patients with who cns grade 3 or 4 glioma: a lesion-function and resting-state fmri analysis |
topic | Case Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992025/ https://www.ncbi.nlm.nih.gov/pubmed/36750534 http://dx.doi.org/10.1007/s11060-023-04254-1 |
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