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PROMIS-29 and EORTC QLQ-C30: an empirical investigation towards a common conception of health

PURPOSE: The assessment of health-related quality of life (HRQOL) measured via patient-reported outcomes (PROs) is a key component in clinical trials and increasingly used in clinical routine worldwide. Two PRO measures (PROMs) that share the same definition of health and report outcomes on a compar...

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Autores principales: Hartmann, Claudia, Fischer, Felix, Klapproth, Christoph P., Röhle, Robert, Rose, Matthias, Karsten, Maria M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992045/
https://www.ncbi.nlm.nih.gov/pubmed/36617606
http://dx.doi.org/10.1007/s11136-022-03324-7
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author Hartmann, Claudia
Fischer, Felix
Klapproth, Christoph P.
Röhle, Robert
Rose, Matthias
Karsten, Maria M.
author_facet Hartmann, Claudia
Fischer, Felix
Klapproth, Christoph P.
Röhle, Robert
Rose, Matthias
Karsten, Maria M.
author_sort Hartmann, Claudia
collection PubMed
description PURPOSE: The assessment of health-related quality of life (HRQOL) measured via patient-reported outcomes (PROs) is a key component in clinical trials and increasingly used in clinical routine worldwide. Two PRO measures (PROMs) that share the same definition of health and report outcomes on a comparable T-metric anchored to general population samples are the PROMIS-29 and the EORTC QLQ-C30. In this study, we investigate the empirical agreement of these underlying concepts. METHODS: We collected PROMIS-29 and EORTC QLQ-C30 data from 1,478 female patients at a breast cancer outpatient centre. We calculated descriptive statistics and correlations between the subscales of both instruments. We performed exploratory (EFA) and confirmatory factor analysis (CFA) in randomly split subsamples in order to assess the underlying psychometric structure of both instruments. RESULTS: The cohort (mean age = 47.4, ± 14.49) reported comparable mean HRQOL scores between the corresponding subscales of both instruments similar to general population reference values. Correlation between the corresponding subscales of both instruments ranged between 0.59 (Social Role) and 0.78 (Physical Functioning). Both an exploratory and a theoretically driven confirmatory factor analysis provided further support for conceptual agreement of the scales. CONCLUSION: EORTC QLQ-C30 and PROMIS-29 showed similar scores and satisfactory agreement in conceptional and statistical analysis. This suggests that the underlying conceptualization of health is reasonably close. Hence, the development of score transformation algorithms or calibration of both instruments on common scales could prospectively increase the comparability of clinical and research PRO data collected with either instrument. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11136-022-03324-7.
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spelling pubmed-99920452023-03-09 PROMIS-29 and EORTC QLQ-C30: an empirical investigation towards a common conception of health Hartmann, Claudia Fischer, Felix Klapproth, Christoph P. Röhle, Robert Rose, Matthias Karsten, Maria M. Qual Life Res Article PURPOSE: The assessment of health-related quality of life (HRQOL) measured via patient-reported outcomes (PROs) is a key component in clinical trials and increasingly used in clinical routine worldwide. Two PRO measures (PROMs) that share the same definition of health and report outcomes on a comparable T-metric anchored to general population samples are the PROMIS-29 and the EORTC QLQ-C30. In this study, we investigate the empirical agreement of these underlying concepts. METHODS: We collected PROMIS-29 and EORTC QLQ-C30 data from 1,478 female patients at a breast cancer outpatient centre. We calculated descriptive statistics and correlations between the subscales of both instruments. We performed exploratory (EFA) and confirmatory factor analysis (CFA) in randomly split subsamples in order to assess the underlying psychometric structure of both instruments. RESULTS: The cohort (mean age = 47.4, ± 14.49) reported comparable mean HRQOL scores between the corresponding subscales of both instruments similar to general population reference values. Correlation between the corresponding subscales of both instruments ranged between 0.59 (Social Role) and 0.78 (Physical Functioning). Both an exploratory and a theoretically driven confirmatory factor analysis provided further support for conceptual agreement of the scales. CONCLUSION: EORTC QLQ-C30 and PROMIS-29 showed similar scores and satisfactory agreement in conceptional and statistical analysis. This suggests that the underlying conceptualization of health is reasonably close. Hence, the development of score transformation algorithms or calibration of both instruments on common scales could prospectively increase the comparability of clinical and research PRO data collected with either instrument. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11136-022-03324-7. Springer International Publishing 2023-01-09 2023 /pmc/articles/PMC9992045/ /pubmed/36617606 http://dx.doi.org/10.1007/s11136-022-03324-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hartmann, Claudia
Fischer, Felix
Klapproth, Christoph P.
Röhle, Robert
Rose, Matthias
Karsten, Maria M.
PROMIS-29 and EORTC QLQ-C30: an empirical investigation towards a common conception of health
title PROMIS-29 and EORTC QLQ-C30: an empirical investigation towards a common conception of health
title_full PROMIS-29 and EORTC QLQ-C30: an empirical investigation towards a common conception of health
title_fullStr PROMIS-29 and EORTC QLQ-C30: an empirical investigation towards a common conception of health
title_full_unstemmed PROMIS-29 and EORTC QLQ-C30: an empirical investigation towards a common conception of health
title_short PROMIS-29 and EORTC QLQ-C30: an empirical investigation towards a common conception of health
title_sort promis-29 and eortc qlq-c30: an empirical investigation towards a common conception of health
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992045/
https://www.ncbi.nlm.nih.gov/pubmed/36617606
http://dx.doi.org/10.1007/s11136-022-03324-7
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