Differences in bioavailability and cognitive-enhancing activity exerted by different crystal polymorphs of latrepirdine (Dimebon(®))

Introduction: Pharmacokinetic characteristics as well as cognitive-enhancing nootropic activity of latrepirdine (Dimebon(®)) in relationship with its polymorphic forms have been studied in SD and Wistar rats. Methods: The pharmacokinetics of six polymorphs (A, B, C, D, E, F) of latrepirdine were stu...

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Detalles Bibliográficos
Autores principales: Gorin, Boris I., Tukhovskaya, Elena A., Ismailova, Alina M., Slashcheva, Gulsara A., Lenina, Oksana A., Petrov, Konstantin A., Kazeev, Ilya V., Murashev, Arkady N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992171/
https://www.ncbi.nlm.nih.gov/pubmed/36909182
http://dx.doi.org/10.3389/fphar.2023.1091858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992171/
https://www.ncbi.nlm.nih.gov/pubmed/36909182
http://dx.doi.org/10.3389/fphar.2023.1091858

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