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PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol

Introduction: A physiologically based pharmacokinetic (PBPK) model for 3-chloroallyl alcohol (3-CAA) was developed and used to evaluate the design of assays for the in vivo genotoxicity of 3-CAA. Methods: Model development was supported by read across from a published PBPK model for ethanol. Read ac...

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Detalles Bibliográficos
Autores principales:	Conolly, Rory P., Clewell, Harvey J., Moore, Martha M., Campbell, Jerry L., Cheng, Wanyun, Gentry, R. Robinan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992188/ https://www.ncbi.nlm.nih.gov/pubmed/36909196 http://dx.doi.org/10.3389/fphar.2023.1088011

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