Limitations of gene editing assessments in human preimplantation embryos

Range of DNA repair in response to double-strand breaks induced in human preimplantation embryos remains uncertain due to the complexity of analyzing single- or few-cell samples. Sequencing of such minute DNA input requires a whole genome amplification that can introduce artifacts, including coverag...

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Detalles Bibliográficos
Autores principales: Liang, Dan, Mikhalchenko, Aleksei, Ma, Hong, Marti Gutierrez, Nuria, Chen, Tailai, Lee, Yeonmi, Park, Sang-Wook, Tippner-Hedges, Rebecca, Koski, Amy, Darby, Hayley, Li, Ying, Van Dyken, Crystal, Zhao, Han, Wu, Keliang, Zhang, Jingye, Hou, Zhenzhen, So, Seongjun, Han, Jongsuk, Park, Jumi, Kim, Chong-Jai, Zong, Kai, Gong, Jianhui, Yuan, Yilin, Gu, Ying, Shen, Yue, Olson, Susan B., Yang, Hui, Battaglia, David, O’Leary, Thomas, Krieg, Sacha A., Lee, David M., Wu, Diana H., Duell, P. Barton, Kaul, Sanjiv, Kim, Jin-Soo, Heitner, Stephen B., Kang, Eunju, Chen, Zi-Jiang, Amato, Paula, Mitalipov, Shoukhrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992379/
https://www.ncbi.nlm.nih.gov/pubmed/36882397
http://dx.doi.org/10.1038/s41467-023-36820-6

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