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Platelet-instructed SPP1(+) macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner

Fibrosis represents the common end stage of chronic organ injury independent of the initial insult, destroying tissue architecture and driving organ failure. Here we discover a population of profibrotic macrophages marked by expression of Spp1, Fn1, and Arg1 (termed Spp1 macrophages), which expands...

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Detalles Bibliográficos
Autores principales:	Hoeft, Konrad, Schaefer, Gideon J.L., Kim, Hyojin, Schumacher, David, Bleckwehl, Tore, Long, Qingqing, Klinkhammer, Barbara Mara, Peisker, Fabian, Koch, Lars, Nagai, James, Halder, Maurice, Ziegler, Susanne, Liehn, Elisa, Kuppe, Christoph, Kranz, Jennifer, Menzel, Sylvia, Costa, Ivan, Wahida, Adam, Boor, Peter, Schneider, Rebekka K., Hayat, Sikander, Kramann, Rafael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992450/ https://www.ncbi.nlm.nih.gov/pubmed/36807143 http://dx.doi.org/10.1016/j.celrep.2023.112131

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