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Global trends in the burden of esophageal cancer, 1990−2019: results from the Global Burden of Disease Study 2019

BACKGROUND: Esophageal cancer is one of the leading causes of cancer death worldwide. A deeper understanding of the trends in annual incidence, mortality, and disability-adjusted life-years (DALYs) of esophageal cancer is critical for management and prevention. In this study, we report on the diseas...

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Autores principales: Jiang, Yu, Lin, Yuechun, Wen, Yaokai, Fu, Wenhai, Wang, Rui, He, Jiaxi, Zhang, Jianrong, Wang, Zhufeng, Ge, Fan, Huo, Zhenyu, Wang, Runchen, Peng, Haoxin, Wu, Xiangrong, He, Jianxing, Li, Shuben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992583/
https://www.ncbi.nlm.nih.gov/pubmed/36910098
http://dx.doi.org/10.21037/jtd-22-856
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author Jiang, Yu
Lin, Yuechun
Wen, Yaokai
Fu, Wenhai
Wang, Rui
He, Jiaxi
Zhang, Jianrong
Wang, Zhufeng
Ge, Fan
Huo, Zhenyu
Wang, Runchen
Peng, Haoxin
Wu, Xiangrong
He, Jianxing
Li, Shuben
author_facet Jiang, Yu
Lin, Yuechun
Wen, Yaokai
Fu, Wenhai
Wang, Rui
He, Jiaxi
Zhang, Jianrong
Wang, Zhufeng
Ge, Fan
Huo, Zhenyu
Wang, Runchen
Peng, Haoxin
Wu, Xiangrong
He, Jianxing
Li, Shuben
author_sort Jiang, Yu
collection PubMed
description BACKGROUND: Esophageal cancer is one of the leading causes of cancer death worldwide. A deeper understanding of the trends in annual incidence, mortality, and disability-adjusted life-years (DALYs) of esophageal cancer is critical for management and prevention. In this study, we report on the disease burden of esophageal cancer in 204 countries and territories between 1990 and 2019 by age, sex, and sociodemographic index (SDI). METHODS: Data on incidence, mortality, and DALYs were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. The estimated numbers and age-standardized rates for esophageal cancer in 2019 are presented in this paper, as well as trends from 1990 to 2019. All estimates are presented as counts and age-standardized rates per 100,000 population, with 95% uncertainty intervals (UIs) for each estimate. RESULTS: In 2019, nearly 535,000 (95% UI: 467,000−595,000) new cases of esophageal cancer occurred globally. Esophageal cancer was responsible for more than 498,000 (95% UI: 438,000−551,000) deaths and 11.7 million (95% UI: 10.4−12.9 million) DALYs. Worldwide age-standardized rates of esophageal cancer, including incidence, deaths, and DALYs, have declined since 1990. However, the trends differ across countries and territories. Notably, there was a nonlinear but generally inverse correlation between age-standardized DALY rates and SDI. Higher age-standardized incidence and death rates were observed in males compared to females, and both increased with age. Regarding risk factors, smoking, alcohol use, and high body-mass index were 3 predominant contributors to esophageal cancer DALYs in 2019 for both sexes worldwide. CONCLUSIONS: This study found a global reduction in the esophageal cancer burden, but substantial heterogeneity remains across regions and countries. Hence, the identification of high-risk groups and the exploration of specific local strategies and primary prevention efforts are required.
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spelling pubmed-99925832023-03-09 Global trends in the burden of esophageal cancer, 1990−2019: results from the Global Burden of Disease Study 2019 Jiang, Yu Lin, Yuechun Wen, Yaokai Fu, Wenhai Wang, Rui He, Jiaxi Zhang, Jianrong Wang, Zhufeng Ge, Fan Huo, Zhenyu Wang, Runchen Peng, Haoxin Wu, Xiangrong He, Jianxing Li, Shuben J Thorac Dis Original Article BACKGROUND: Esophageal cancer is one of the leading causes of cancer death worldwide. A deeper understanding of the trends in annual incidence, mortality, and disability-adjusted life-years (DALYs) of esophageal cancer is critical for management and prevention. In this study, we report on the disease burden of esophageal cancer in 204 countries and territories between 1990 and 2019 by age, sex, and sociodemographic index (SDI). METHODS: Data on incidence, mortality, and DALYs were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. The estimated numbers and age-standardized rates for esophageal cancer in 2019 are presented in this paper, as well as trends from 1990 to 2019. All estimates are presented as counts and age-standardized rates per 100,000 population, with 95% uncertainty intervals (UIs) for each estimate. RESULTS: In 2019, nearly 535,000 (95% UI: 467,000−595,000) new cases of esophageal cancer occurred globally. Esophageal cancer was responsible for more than 498,000 (95% UI: 438,000−551,000) deaths and 11.7 million (95% UI: 10.4−12.9 million) DALYs. Worldwide age-standardized rates of esophageal cancer, including incidence, deaths, and DALYs, have declined since 1990. However, the trends differ across countries and territories. Notably, there was a nonlinear but generally inverse correlation between age-standardized DALY rates and SDI. Higher age-standardized incidence and death rates were observed in males compared to females, and both increased with age. Regarding risk factors, smoking, alcohol use, and high body-mass index were 3 predominant contributors to esophageal cancer DALYs in 2019 for both sexes worldwide. CONCLUSIONS: This study found a global reduction in the esophageal cancer burden, but substantial heterogeneity remains across regions and countries. Hence, the identification of high-risk groups and the exploration of specific local strategies and primary prevention efforts are required. AME Publishing Company 2023-02-01 2023-02-28 /pmc/articles/PMC9992583/ /pubmed/36910098 http://dx.doi.org/10.21037/jtd-22-856 Text en 2023 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Jiang, Yu
Lin, Yuechun
Wen, Yaokai
Fu, Wenhai
Wang, Rui
He, Jiaxi
Zhang, Jianrong
Wang, Zhufeng
Ge, Fan
Huo, Zhenyu
Wang, Runchen
Peng, Haoxin
Wu, Xiangrong
He, Jianxing
Li, Shuben
Global trends in the burden of esophageal cancer, 1990−2019: results from the Global Burden of Disease Study 2019
title Global trends in the burden of esophageal cancer, 1990−2019: results from the Global Burden of Disease Study 2019
title_full Global trends in the burden of esophageal cancer, 1990−2019: results from the Global Burden of Disease Study 2019
title_fullStr Global trends in the burden of esophageal cancer, 1990−2019: results from the Global Burden of Disease Study 2019
title_full_unstemmed Global trends in the burden of esophageal cancer, 1990−2019: results from the Global Burden of Disease Study 2019
title_short Global trends in the burden of esophageal cancer, 1990−2019: results from the Global Burden of Disease Study 2019
title_sort global trends in the burden of esophageal cancer, 1990−2019: results from the global burden of disease study 2019
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992583/
https://www.ncbi.nlm.nih.gov/pubmed/36910098
http://dx.doi.org/10.21037/jtd-22-856
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