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HIV associated cell death: Peptide-induced apoptosis restricts viral transmission
The human immunodeficiency virus (HIV) is still a global pandemic and despite the successful use of anti-retroviral therapy, a well-established cure remains to be identified. Viral modulation of cell death has a significant role in HIV pathogenesis. Here we sought to understand the major mechanisms...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992636/ https://www.ncbi.nlm.nih.gov/pubmed/36911666 http://dx.doi.org/10.3389/fimmu.2023.1096759 |
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author | Chen, Qiongyu Zhao, Yan Zhang, Yonghong Zhang, Jianbo Lu, Wenshu Chang, Chih-Hao Jiang, Shisong |
author_facet | Chen, Qiongyu Zhao, Yan Zhang, Yonghong Zhang, Jianbo Lu, Wenshu Chang, Chih-Hao Jiang, Shisong |
author_sort | Chen, Qiongyu |
collection | PubMed |
description | The human immunodeficiency virus (HIV) is still a global pandemic and despite the successful use of anti-retroviral therapy, a well-established cure remains to be identified. Viral modulation of cell death has a significant role in HIV pathogenesis. Here we sought to understand the major mechanisms of HIV-induced death of lymphocytes and the effects on viral transmission. Flow cytometry analysis of lymphocytes from five latent HIV-infected patients, and HIV IIIB-infected MT2 cells demonstrated both necrosis and apoptosis to be the major mechanisms of cell death in CD4(+) and CD4(-)/CD8(-) lymphocytes. Significantly, pro-apoptotic tumor necrosis factor (TNF) peptide (P13) was found to inhibit HIV-related cell death and reduced viral transmission. Whereas pro-necrotic TNF peptide (P16) had little effect on HIV-related cell death and viral transmission. Understanding mechanisms by which cell death can be manipulated may provide additional drug targets to reduce the loss of CD4(+) cells and the formation of a viral reservoir in HIV infection. |
format | Online Article Text |
id | pubmed-9992636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99926362023-03-09 HIV associated cell death: Peptide-induced apoptosis restricts viral transmission Chen, Qiongyu Zhao, Yan Zhang, Yonghong Zhang, Jianbo Lu, Wenshu Chang, Chih-Hao Jiang, Shisong Front Immunol Immunology The human immunodeficiency virus (HIV) is still a global pandemic and despite the successful use of anti-retroviral therapy, a well-established cure remains to be identified. Viral modulation of cell death has a significant role in HIV pathogenesis. Here we sought to understand the major mechanisms of HIV-induced death of lymphocytes and the effects on viral transmission. Flow cytometry analysis of lymphocytes from five latent HIV-infected patients, and HIV IIIB-infected MT2 cells demonstrated both necrosis and apoptosis to be the major mechanisms of cell death in CD4(+) and CD4(-)/CD8(-) lymphocytes. Significantly, pro-apoptotic tumor necrosis factor (TNF) peptide (P13) was found to inhibit HIV-related cell death and reduced viral transmission. Whereas pro-necrotic TNF peptide (P16) had little effect on HIV-related cell death and viral transmission. Understanding mechanisms by which cell death can be manipulated may provide additional drug targets to reduce the loss of CD4(+) cells and the formation of a viral reservoir in HIV infection. Frontiers Media S.A. 2023-02-22 /pmc/articles/PMC9992636/ /pubmed/36911666 http://dx.doi.org/10.3389/fimmu.2023.1096759 Text en Copyright © 2023 Chen, Zhao, Zhang, Zhang, Lu, Chang and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Chen, Qiongyu Zhao, Yan Zhang, Yonghong Zhang, Jianbo Lu, Wenshu Chang, Chih-Hao Jiang, Shisong HIV associated cell death: Peptide-induced apoptosis restricts viral transmission |
title | HIV associated cell death: Peptide-induced apoptosis restricts viral transmission |
title_full | HIV associated cell death: Peptide-induced apoptosis restricts viral transmission |
title_fullStr | HIV associated cell death: Peptide-induced apoptosis restricts viral transmission |
title_full_unstemmed | HIV associated cell death: Peptide-induced apoptosis restricts viral transmission |
title_short | HIV associated cell death: Peptide-induced apoptosis restricts viral transmission |
title_sort | hiv associated cell death: peptide-induced apoptosis restricts viral transmission |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992636/ https://www.ncbi.nlm.nih.gov/pubmed/36911666 http://dx.doi.org/10.3389/fimmu.2023.1096759 |
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