Verteporfin-induced proteotoxicity impairs cell homeostasis and survival in neuroblastoma subtypes independent of YAP/TAZ expression

Neuroblastoma (NB) is a highly aggressive extracranial solid tumor in children. Due to its heterogeneity, NB remains a therapeutic challenge. Several oncogenic factors, including the Hippo effectors YAP/TAZ, are associated with NB tumorigenesis. Verteporfin (VPF) is an FDA-approved drug shown to dir...

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Detalles Bibliográficos
Autores principales: Condurat, Alexandra-Larisa, Aminzadeh-Gohari, Sepideh, Malnar, Mirjana, Schider, Nicole, Opitz, Leonie, Thomas, Ria, Menon, Vishal, Kofler, Barbara, Pruszak, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992669/
https://www.ncbi.nlm.nih.gov/pubmed/36882436
http://dx.doi.org/10.1038/s41598-023-29796-2

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