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A potential link between aberrant expression of ECRG4 and atrial fibrillation

Esophageal cancer-related gene-4 (ECRG4), a 148-amino acid propertied and new tumor suppressor, is initially cloned from the normal esophageal epithelium. ECRG4 was found to be expressed not only in esophageal tissues but also in cardiomyocytes. Previous studies demonstrated that ECRG4 is constituti...

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Autores principales: Zhang, Zuojing, Wang, Wei, Zhang, Yuxin, You, Xingji, Wu, Jingxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992723/
https://www.ncbi.nlm.nih.gov/pubmed/36910669
http://dx.doi.org/10.3389/fonc.2023.1031128
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author Zhang, Zuojing
Wang, Wei
Zhang, Yuxin
You, Xingji
Wu, Jingxiang
author_facet Zhang, Zuojing
Wang, Wei
Zhang, Yuxin
You, Xingji
Wu, Jingxiang
author_sort Zhang, Zuojing
collection PubMed
description Esophageal cancer-related gene-4 (ECRG4), a 148-amino acid propertied and new tumor suppressor, is initially cloned from the normal esophageal epithelium. ECRG4 was found to be expressed not only in esophageal tissues but also in cardiomyocytes. Previous studies demonstrated that ECRG4 is constitutively expressed in esophageal epithelial cells, and its degree of downregulation is directly proportional to prognosis in patients with esophageal cancer. In the heart, ECRG4 shows greater expression in the atria than in the ventricles, which accounts for its heterogeneity. Downregulation of ECRG4 expression level correlates with esophageal cancer, as well as myocardial injuries and arrhythmias. As a result, this review summarizes the possible susceptibility gene, ECRG4 and its associated molecular mechanisms in cancer patients with atrial fibrillation and myocardial injury. The review begins by describing ECRG4’s biological background, discusses its expression in the cardiovascular system, lists the clinical and animal research related to the downregulation of ECRG4 in atrial fibrillation, and focuses on its potential role in atrial fibrillation. Downregulation of ECRG4 may increase the risk of atrial fibrillation by affecting ion channels, MMPs expression and inflammatory response. We will then discuss how ECRG4 can be used in the treatment of tumors and arrhythmias, and provide a novel possible strategy to reduce the occurrence of perioperative cardiovascular adverse events in patients with tumors such as esophageal cancer and gastric cancer.
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spelling pubmed-99927232023-03-09 A potential link between aberrant expression of ECRG4 and atrial fibrillation Zhang, Zuojing Wang, Wei Zhang, Yuxin You, Xingji Wu, Jingxiang Front Oncol Oncology Esophageal cancer-related gene-4 (ECRG4), a 148-amino acid propertied and new tumor suppressor, is initially cloned from the normal esophageal epithelium. ECRG4 was found to be expressed not only in esophageal tissues but also in cardiomyocytes. Previous studies demonstrated that ECRG4 is constitutively expressed in esophageal epithelial cells, and its degree of downregulation is directly proportional to prognosis in patients with esophageal cancer. In the heart, ECRG4 shows greater expression in the atria than in the ventricles, which accounts for its heterogeneity. Downregulation of ECRG4 expression level correlates with esophageal cancer, as well as myocardial injuries and arrhythmias. As a result, this review summarizes the possible susceptibility gene, ECRG4 and its associated molecular mechanisms in cancer patients with atrial fibrillation and myocardial injury. The review begins by describing ECRG4’s biological background, discusses its expression in the cardiovascular system, lists the clinical and animal research related to the downregulation of ECRG4 in atrial fibrillation, and focuses on its potential role in atrial fibrillation. Downregulation of ECRG4 may increase the risk of atrial fibrillation by affecting ion channels, MMPs expression and inflammatory response. We will then discuss how ECRG4 can be used in the treatment of tumors and arrhythmias, and provide a novel possible strategy to reduce the occurrence of perioperative cardiovascular adverse events in patients with tumors such as esophageal cancer and gastric cancer. Frontiers Media S.A. 2023-02-22 /pmc/articles/PMC9992723/ /pubmed/36910669 http://dx.doi.org/10.3389/fonc.2023.1031128 Text en Copyright © 2023 Zhang, Wang, Zhang, You and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Zuojing
Wang, Wei
Zhang, Yuxin
You, Xingji
Wu, Jingxiang
A potential link between aberrant expression of ECRG4 and atrial fibrillation
title A potential link between aberrant expression of ECRG4 and atrial fibrillation
title_full A potential link between aberrant expression of ECRG4 and atrial fibrillation
title_fullStr A potential link between aberrant expression of ECRG4 and atrial fibrillation
title_full_unstemmed A potential link between aberrant expression of ECRG4 and atrial fibrillation
title_short A potential link between aberrant expression of ECRG4 and atrial fibrillation
title_sort potential link between aberrant expression of ecrg4 and atrial fibrillation
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992723/
https://www.ncbi.nlm.nih.gov/pubmed/36910669
http://dx.doi.org/10.3389/fonc.2023.1031128
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