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Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain

Numerous studies have investigated the impacts of common types of chronic pain (CP) on patients’ cognitive function and observed that CP was associated with later dementia. More recently, there is a growing recognition that CP conditions frequently coexist at multiple body sites and may bring more b...

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Autores principales: Zhao, Wenhui, Zhao, Lei, Chang, Xiangyu, Lu, Xuejing, Tu, Yiheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992778/
https://www.ncbi.nlm.nih.gov/pubmed/36802440
http://dx.doi.org/10.1073/pnas.2215192120
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author Zhao, Wenhui
Zhao, Lei
Chang, Xiangyu
Lu, Xuejing
Tu, Yiheng
author_facet Zhao, Wenhui
Zhao, Lei
Chang, Xiangyu
Lu, Xuejing
Tu, Yiheng
author_sort Zhao, Wenhui
collection PubMed
description Numerous studies have investigated the impacts of common types of chronic pain (CP) on patients’ cognitive function and observed that CP was associated with later dementia. More recently, there is a growing recognition that CP conditions frequently coexist at multiple body sites and may bring more burdens on patients’ overall health. However, whether and how multisite CP (MCP) contributes to an increased risk of dementia, compared to single-site CP (SCP) and pain-free (PF), is largely unclear. In the current study, utilizing the UK Biobank cohort, we first investigated dementia risk in individuals (n = 354,943) with different numbers of coexisting CP sites using Cox proportional hazards regression models. We then applied generalized additive models to investigate whether MCP leads to excessive deterioration of participants’ (n = 19,116) cognition and brain structure. We found that individuals with MCP were associated with significantly higher dementia risk, broader and faster cognitive impairment, and greater hippocampal atrophy than both PF individuals and those with SCP. Moreover, the detrimental effects of MCP on dementia risk and hippocampal volume aggravated along with the number of coexisting CP sites. Mediation analyses further revealed that the decline of fluid intelligence in MCP individuals was partially mediated by hippocampal atrophy. Our results suggested that cognitive decline and hippocampal atrophy interact biologically and may underlie the increased risk of dementia associated with MCP.
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spelling pubmed-99927782023-08-21 Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain Zhao, Wenhui Zhao, Lei Chang, Xiangyu Lu, Xuejing Tu, Yiheng Proc Natl Acad Sci U S A Biological Sciences Numerous studies have investigated the impacts of common types of chronic pain (CP) on patients’ cognitive function and observed that CP was associated with later dementia. More recently, there is a growing recognition that CP conditions frequently coexist at multiple body sites and may bring more burdens on patients’ overall health. However, whether and how multisite CP (MCP) contributes to an increased risk of dementia, compared to single-site CP (SCP) and pain-free (PF), is largely unclear. In the current study, utilizing the UK Biobank cohort, we first investigated dementia risk in individuals (n = 354,943) with different numbers of coexisting CP sites using Cox proportional hazards regression models. We then applied generalized additive models to investigate whether MCP leads to excessive deterioration of participants’ (n = 19,116) cognition and brain structure. We found that individuals with MCP were associated with significantly higher dementia risk, broader and faster cognitive impairment, and greater hippocampal atrophy than both PF individuals and those with SCP. Moreover, the detrimental effects of MCP on dementia risk and hippocampal volume aggravated along with the number of coexisting CP sites. Mediation analyses further revealed that the decline of fluid intelligence in MCP individuals was partially mediated by hippocampal atrophy. Our results suggested that cognitive decline and hippocampal atrophy interact biologically and may underlie the increased risk of dementia associated with MCP. National Academy of Sciences 2023-02-21 2023-02-28 /pmc/articles/PMC9992778/ /pubmed/36802440 http://dx.doi.org/10.1073/pnas.2215192120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Zhao, Wenhui
Zhao, Lei
Chang, Xiangyu
Lu, Xuejing
Tu, Yiheng
Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain
title Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain
title_full Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain
title_fullStr Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain
title_full_unstemmed Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain
title_short Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain
title_sort elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992778/
https://www.ncbi.nlm.nih.gov/pubmed/36802440
http://dx.doi.org/10.1073/pnas.2215192120
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