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Cerebellar control of a unitary head direction sense
The head-direction (HD) system, a key neural circuit for navigation, consists of several anatomical structures containing neurons selective to the animal’s head direction. HD cells exhibit ubiquitous temporal coordination across brain regions, independently of the animal’s behavioral state or sensor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992783/ https://www.ncbi.nlm.nih.gov/pubmed/36812198 http://dx.doi.org/10.1073/pnas.2214539120 |
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author | Fallahnezhad, Mehdi Le Mero, Julia Zenelaj, Xhensjana Vincent, Jean Rochefort, Christelle Rondi-Reig, Laure |
author_facet | Fallahnezhad, Mehdi Le Mero, Julia Zenelaj, Xhensjana Vincent, Jean Rochefort, Christelle Rondi-Reig, Laure |
author_sort | Fallahnezhad, Mehdi |
collection | PubMed |
description | The head-direction (HD) system, a key neural circuit for navigation, consists of several anatomical structures containing neurons selective to the animal’s head direction. HD cells exhibit ubiquitous temporal coordination across brain regions, independently of the animal’s behavioral state or sensory inputs. Such temporal coordination mediates a single, stable, and persistent HD signal, which is essential for intact orientation. However, the mechanistic processes behind the temporal organization of HD cells are unknown. By manipulating the cerebellum, we identify pairs of HD cells recorded from two brain structures (anterodorsal thalamus and retrosplenial cortex) that lose their temporal coordination, specifically during the removal of the external sensory inputs. Further, we identify distinct cerebellar mechanisms that participate in the spatial stability of the HD signal depending on sensory signals. We show that while cerebellar protein phosphatase 2B-dependent mechanisms facilitate the anchoring of the HD signal on the external cues, the cerebellar protein kinase C-dependent mechanisms are required for the stability of the HD signal by self-motion cues. These results indicate that the cerebellum contributes to the preservation of a single and stable sense of direction. |
format | Online Article Text |
id | pubmed-9992783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-99927832023-08-22 Cerebellar control of a unitary head direction sense Fallahnezhad, Mehdi Le Mero, Julia Zenelaj, Xhensjana Vincent, Jean Rochefort, Christelle Rondi-Reig, Laure Proc Natl Acad Sci U S A Biological Sciences The head-direction (HD) system, a key neural circuit for navigation, consists of several anatomical structures containing neurons selective to the animal’s head direction. HD cells exhibit ubiquitous temporal coordination across brain regions, independently of the animal’s behavioral state or sensory inputs. Such temporal coordination mediates a single, stable, and persistent HD signal, which is essential for intact orientation. However, the mechanistic processes behind the temporal organization of HD cells are unknown. By manipulating the cerebellum, we identify pairs of HD cells recorded from two brain structures (anterodorsal thalamus and retrosplenial cortex) that lose their temporal coordination, specifically during the removal of the external sensory inputs. Further, we identify distinct cerebellar mechanisms that participate in the spatial stability of the HD signal depending on sensory signals. We show that while cerebellar protein phosphatase 2B-dependent mechanisms facilitate the anchoring of the HD signal on the external cues, the cerebellar protein kinase C-dependent mechanisms are required for the stability of the HD signal by self-motion cues. These results indicate that the cerebellum contributes to the preservation of a single and stable sense of direction. National Academy of Sciences 2023-02-22 2023-02-28 /pmc/articles/PMC9992783/ /pubmed/36812198 http://dx.doi.org/10.1073/pnas.2214539120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Fallahnezhad, Mehdi Le Mero, Julia Zenelaj, Xhensjana Vincent, Jean Rochefort, Christelle Rondi-Reig, Laure Cerebellar control of a unitary head direction sense |
title | Cerebellar control of a unitary head direction sense |
title_full | Cerebellar control of a unitary head direction sense |
title_fullStr | Cerebellar control of a unitary head direction sense |
title_full_unstemmed | Cerebellar control of a unitary head direction sense |
title_short | Cerebellar control of a unitary head direction sense |
title_sort | cerebellar control of a unitary head direction sense |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992783/ https://www.ncbi.nlm.nih.gov/pubmed/36812198 http://dx.doi.org/10.1073/pnas.2214539120 |
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