Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1

Liver X receptor (LXR) is a critical regulator of cholesterol homeostasis that inhibits T cell receptor (TCR)-induced proliferation by altering intracellular sterol metabolism. However, the mechanisms by which LXR regulates helper T cell subset differentiation remain unclear. Here, we demonstrate th...

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Detalles Bibliográficos
Autores principales: Kim, Jiyeon, Lee, Haeseung, Lee, Jeong-Eun, Choi, Garam, Chung, Hayeon, Kim, Daehong, Park, Min Jung, Gye, Yong Seok, Shin, Kwang-Soo, Kang, Chang-Yuil, Kwok, Seung-Ki, Chung, Yeonseok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992818/
https://www.ncbi.nlm.nih.gov/pubmed/36802434
http://dx.doi.org/10.1073/pnas.2213793120

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