Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH

The aggregation of α-synuclein into amyloid fibrils has been under scrutiny in recent years because of its association with Parkinson’s disease. This process can be triggered by a lipid-dependent nucleation process, and the resulting aggregates can proliferate through secondary nucleation under acid...

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Detalles Bibliográficos
Autores principales: Dada, Samuel T., Hardenberg, Maarten C., Toprakcioglu, Zenon, Mrugalla, Lena K., Cali, Mariana P., McKeon, Mollie O., Klimont, Ewa, Michaels, Thomas C. T., Knowles, Tuomas P. J., Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992821/
https://www.ncbi.nlm.nih.gov/pubmed/36802433
http://dx.doi.org/10.1073/pnas.2208792120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992821/
https://www.ncbi.nlm.nih.gov/pubmed/36802433
http://dx.doi.org/10.1073/pnas.2208792120

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