Titin activates myosin filaments in skeletal muscle by switching from an extensible spring to a mechanical rectifier

Titin is a molecular spring in parallel with myosin motors in each muscle half-sarcomere, responsible for passive force development at sarcomere length (SL) above the physiological range (>2.7 μm). The role of titin at physiological SL is unclear and is investigated here in single intact muscle c...

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Detalles Bibliográficos
Autores principales: Squarci, Caterina, Bianco, Pasquale, Reconditi, Massimo, Pertici, Irene, Caremani, Marco, Narayanan, Theyencheri, Horváth, Ádám I., Málnási-Csizmadia, András, Linari, Marco, Lombardi, Vincenzo, Piazzesi, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992839/
https://www.ncbi.nlm.nih.gov/pubmed/36812205
http://dx.doi.org/10.1073/pnas.2219346120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992839/
https://www.ncbi.nlm.nih.gov/pubmed/36812205
http://dx.doi.org/10.1073/pnas.2219346120

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