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The burden of childhood and adolescent cancers in North Africa and the Middle East (NAME) region: findings from the Global Burden of Disease study 2019

INTRODUCTION: Despite the significant burden of childhood and adolescent cancers, no specific studies recently discussed the burden of cancer in this group in the North Africa and the Middle East (NAME) region. Therefore, we aimed to study the burden of cancers in this group in this region. MATERIAL...

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Autores principales: Karimi, Amirali, Saeedi Moghaddam, Sahar, Azadnajafabad, Sina, Esfahani, Zahra, Sharifnejad Tehrani, Yeganeh, Abbasi-Kangevari, Mohsen, Shobeiri, Parnian, Ghamari, Seyyed-Hadi, Masinaei, Masoud, Rezaei, Nazila, Shahin, Sarvenaz, Rayzan, Elham, Rezaei, Negar, Larijani, Bagher, Kompani, Farzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992906/
https://www.ncbi.nlm.nih.gov/pubmed/36890483
http://dx.doi.org/10.1186/s12887-023-03931-4
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author Karimi, Amirali
Saeedi Moghaddam, Sahar
Azadnajafabad, Sina
Esfahani, Zahra
Sharifnejad Tehrani, Yeganeh
Abbasi-Kangevari, Mohsen
Shobeiri, Parnian
Ghamari, Seyyed-Hadi
Masinaei, Masoud
Rezaei, Nazila
Shahin, Sarvenaz
Rayzan, Elham
Rezaei, Negar
Larijani, Bagher
Kompani, Farzad
author_facet Karimi, Amirali
Saeedi Moghaddam, Sahar
Azadnajafabad, Sina
Esfahani, Zahra
Sharifnejad Tehrani, Yeganeh
Abbasi-Kangevari, Mohsen
Shobeiri, Parnian
Ghamari, Seyyed-Hadi
Masinaei, Masoud
Rezaei, Nazila
Shahin, Sarvenaz
Rayzan, Elham
Rezaei, Negar
Larijani, Bagher
Kompani, Farzad
author_sort Karimi, Amirali
collection PubMed
description INTRODUCTION: Despite the significant burden of childhood and adolescent cancers, no specific studies recently discussed the burden of cancer in this group in the North Africa and the Middle East (NAME) region. Therefore, we aimed to study the burden of cancers in this group in this region. MATERIALS AND METHODS: We retrieved the Global Burden of Disease (GBD) data for children and adolescent cancers (0–19 years old) in the NAME region from 1990 to 2019. 21 types of neoplasms were grouped as “neoplasms”, comprising 19 specific cancer groups as well as “other malignant neoplasms” and “other neoplasms”. Three significant parameters of incidence, deaths, and Disability-Adjusted Life Years (DALYs) were studied. The data are presented with 95% uncertainty intervals (UI), and reported rates per 100,000. RESULTS: In 2019, almost 6 million (95% UI: 4.166 M–8.405 M) new cases and 11,560(9770-13,578) deaths due to neoplasms occurred in the NAME region. Incidence was higher in females (3.4 M), while deaths (6226 of overall 11,560) and DALYs (501,118 of overall 933,885) were estimated as higher in males. Incidence rates did not significantly change since 1990, while deaths and DALYs rates declined significantly. After excluding “other malignant neoplasms” and “other neoplasms”, leukemia was responsible for the highest number of incidence and deaths (incidence: 10,629(8237-13,081), deaths: 4053(3135-5013), followed by brain and central nervous system cancers (incidence: 5897(4192-7134), deaths: 2446(1761-2960)), and non-Hodgkin lymphoma (incidence: 2741 (2237-3392), deaths: 790(645–962)). Incidence rates of neoplasms were similar for most countries, but countries varied more in terms of death rates. Afghanistan 8.9(6.5–11.9), Sudan 6.4(4.5–8.6), and the Syrian Arab Republic 5.6(4.3–8.3) had the highest overall death rates. CONCLUSION: The NAME region is observing relatively constant incidence rates and a decreasing pattern in the deaths and DALYs. Despite this success, several countries are lagging behind in development. Different issues such as economic problems, armed conflicts and political instabilities, lack of equipment or experienced staff or poor distribution, stigmatization and disbelief in the healthcare systems account for unfavorable numbers in some countries. Such problems require urgent solutions as new sophisticated and personalized cares raise the alarm for even more inequalities between high and low-income countries. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-023-03931-4.
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spelling pubmed-99929062023-03-08 The burden of childhood and adolescent cancers in North Africa and the Middle East (NAME) region: findings from the Global Burden of Disease study 2019 Karimi, Amirali Saeedi Moghaddam, Sahar Azadnajafabad, Sina Esfahani, Zahra Sharifnejad Tehrani, Yeganeh Abbasi-Kangevari, Mohsen Shobeiri, Parnian Ghamari, Seyyed-Hadi Masinaei, Masoud Rezaei, Nazila Shahin, Sarvenaz Rayzan, Elham Rezaei, Negar Larijani, Bagher Kompani, Farzad BMC Pediatr Research INTRODUCTION: Despite the significant burden of childhood and adolescent cancers, no specific studies recently discussed the burden of cancer in this group in the North Africa and the Middle East (NAME) region. Therefore, we aimed to study the burden of cancers in this group in this region. MATERIALS AND METHODS: We retrieved the Global Burden of Disease (GBD) data for children and adolescent cancers (0–19 years old) in the NAME region from 1990 to 2019. 21 types of neoplasms were grouped as “neoplasms”, comprising 19 specific cancer groups as well as “other malignant neoplasms” and “other neoplasms”. Three significant parameters of incidence, deaths, and Disability-Adjusted Life Years (DALYs) were studied. The data are presented with 95% uncertainty intervals (UI), and reported rates per 100,000. RESULTS: In 2019, almost 6 million (95% UI: 4.166 M–8.405 M) new cases and 11,560(9770-13,578) deaths due to neoplasms occurred in the NAME region. Incidence was higher in females (3.4 M), while deaths (6226 of overall 11,560) and DALYs (501,118 of overall 933,885) were estimated as higher in males. Incidence rates did not significantly change since 1990, while deaths and DALYs rates declined significantly. After excluding “other malignant neoplasms” and “other neoplasms”, leukemia was responsible for the highest number of incidence and deaths (incidence: 10,629(8237-13,081), deaths: 4053(3135-5013), followed by brain and central nervous system cancers (incidence: 5897(4192-7134), deaths: 2446(1761-2960)), and non-Hodgkin lymphoma (incidence: 2741 (2237-3392), deaths: 790(645–962)). Incidence rates of neoplasms were similar for most countries, but countries varied more in terms of death rates. Afghanistan 8.9(6.5–11.9), Sudan 6.4(4.5–8.6), and the Syrian Arab Republic 5.6(4.3–8.3) had the highest overall death rates. CONCLUSION: The NAME region is observing relatively constant incidence rates and a decreasing pattern in the deaths and DALYs. Despite this success, several countries are lagging behind in development. Different issues such as economic problems, armed conflicts and political instabilities, lack of equipment or experienced staff or poor distribution, stigmatization and disbelief in the healthcare systems account for unfavorable numbers in some countries. Such problems require urgent solutions as new sophisticated and personalized cares raise the alarm for even more inequalities between high and low-income countries. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-023-03931-4. BioMed Central 2023-03-08 /pmc/articles/PMC9992906/ /pubmed/36890483 http://dx.doi.org/10.1186/s12887-023-03931-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Karimi, Amirali
Saeedi Moghaddam, Sahar
Azadnajafabad, Sina
Esfahani, Zahra
Sharifnejad Tehrani, Yeganeh
Abbasi-Kangevari, Mohsen
Shobeiri, Parnian
Ghamari, Seyyed-Hadi
Masinaei, Masoud
Rezaei, Nazila
Shahin, Sarvenaz
Rayzan, Elham
Rezaei, Negar
Larijani, Bagher
Kompani, Farzad
The burden of childhood and adolescent cancers in North Africa and the Middle East (NAME) region: findings from the Global Burden of Disease study 2019
title The burden of childhood and adolescent cancers in North Africa and the Middle East (NAME) region: findings from the Global Burden of Disease study 2019
title_full The burden of childhood and adolescent cancers in North Africa and the Middle East (NAME) region: findings from the Global Burden of Disease study 2019
title_fullStr The burden of childhood and adolescent cancers in North Africa and the Middle East (NAME) region: findings from the Global Burden of Disease study 2019
title_full_unstemmed The burden of childhood and adolescent cancers in North Africa and the Middle East (NAME) region: findings from the Global Burden of Disease study 2019
title_short The burden of childhood and adolescent cancers in North Africa and the Middle East (NAME) region: findings from the Global Burden of Disease study 2019
title_sort burden of childhood and adolescent cancers in north africa and the middle east (name) region: findings from the global burden of disease study 2019
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992906/
https://www.ncbi.nlm.nih.gov/pubmed/36890483
http://dx.doi.org/10.1186/s12887-023-03931-4
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