PARP inhibitors in the treatment of ARID1A mutant ovarian clear cell cancer: PI3K/Akt1-dependent mechanism of synthetic lethality

INTRODUCTION: Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme involved in the repair of DNA single-strand breaks (SSB). The recent development of poly(ADP-ribose) polymerase inhibitors (PARPi) results from over 45 years of studies. When the activity of PARP1 or PARP2 is compromised, DNA SSB l...

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Detalles Bibliográficos
Autores principales: Yakovlev, Vasily A., Sullivan, Stephanie A., Fields, Emma C., Temkin, Sarah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992988/
https://www.ncbi.nlm.nih.gov/pubmed/36910637
http://dx.doi.org/10.3389/fonc.2023.1124147

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