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Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection

BACKGROUND/AIMS: Little is known about the effect of Helicobacter pylori eradication on the recurrence of gastric hyperplastic polyps after endoscopic resection. Thus, we evaluated the recurrence rate of gastric hyperplastic polyps based on H. pylori eradication following endoscopic resection. METHO...

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Autores principales: Cho, Young Sin, Nam, Su Youn, Moon, Hee Seok, Kim, Tae Ho, Kim, Sung Eun, Jung, Jin Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993100/
https://www.ncbi.nlm.nih.gov/pubmed/36437035
http://dx.doi.org/10.3904/kjim.2022.111
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author Cho, Young Sin
Nam, Su Youn
Moon, Hee Seok
Kim, Tae Ho
Kim, Sung Eun
Jung, Jin Tae
author_facet Cho, Young Sin
Nam, Su Youn
Moon, Hee Seok
Kim, Tae Ho
Kim, Sung Eun
Jung, Jin Tae
author_sort Cho, Young Sin
collection PubMed
description BACKGROUND/AIMS: Little is known about the effect of Helicobacter pylori eradication on the recurrence of gastric hyperplastic polyps after endoscopic resection. Thus, we evaluated the recurrence rate of gastric hyperplastic polyps based on H. pylori eradication following endoscopic resection. METHODS: We retrospectively reviewed the medical records of 201 patients with H. pylori infection who underwent endoscopic resection for gastric hyperplastic polyps at six medical centers. H. pylori status was assessed by histological analysis and a rapid urease test. A total of 149 patients underwent successful H. pylori eradication (eradication group), whereas 52 patients had persistent H. pylori infections (non-eradication group). The recurrence rate of gastric hyperplastic polyps and the risk factors according to H. pylori status were analyzed. RESULTS: During the mean follow-up period of 18.3 months, recurrent gastric polyps developed after endoscopic resection in 10 patients (19.2% [10/52]) in the non-eradication group and 12 patients (8.1% [12/149]) in the eradication group. The cumulative incidence of recurrent gastric hyperplastic polyps was significantly higher in the non-eradication group than in the eradication group (p = 0.041, log-rank test). In the adjusted analysis, H. pylori eradication reduced the recurrence of gastric hyperplastic polyps (hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.18 to 0.99), whereas anticoagulation therapy increased the risk of recurrence of gastric hyperplastic polyps (HR, 4.91; 95% CI, 1.39 to 17.28). CONCLUSIONS: Successful eradication of H. pylori may reduce the recurrence of gastric hyperplastic polyps in patients after endoscopic mucosal resection.
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spelling pubmed-99931002023-03-09 Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection Cho, Young Sin Nam, Su Youn Moon, Hee Seok Kim, Tae Ho Kim, Sung Eun Jung, Jin Tae Korean J Intern Med Original Article BACKGROUND/AIMS: Little is known about the effect of Helicobacter pylori eradication on the recurrence of gastric hyperplastic polyps after endoscopic resection. Thus, we evaluated the recurrence rate of gastric hyperplastic polyps based on H. pylori eradication following endoscopic resection. METHODS: We retrospectively reviewed the medical records of 201 patients with H. pylori infection who underwent endoscopic resection for gastric hyperplastic polyps at six medical centers. H. pylori status was assessed by histological analysis and a rapid urease test. A total of 149 patients underwent successful H. pylori eradication (eradication group), whereas 52 patients had persistent H. pylori infections (non-eradication group). The recurrence rate of gastric hyperplastic polyps and the risk factors according to H. pylori status were analyzed. RESULTS: During the mean follow-up period of 18.3 months, recurrent gastric polyps developed after endoscopic resection in 10 patients (19.2% [10/52]) in the non-eradication group and 12 patients (8.1% [12/149]) in the eradication group. The cumulative incidence of recurrent gastric hyperplastic polyps was significantly higher in the non-eradication group than in the eradication group (p = 0.041, log-rank test). In the adjusted analysis, H. pylori eradication reduced the recurrence of gastric hyperplastic polyps (hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.18 to 0.99), whereas anticoagulation therapy increased the risk of recurrence of gastric hyperplastic polyps (HR, 4.91; 95% CI, 1.39 to 17.28). CONCLUSIONS: Successful eradication of H. pylori may reduce the recurrence of gastric hyperplastic polyps in patients after endoscopic mucosal resection. Korean Association of Internal Medicine 2023-03 2022-11-28 /pmc/articles/PMC9993100/ /pubmed/36437035 http://dx.doi.org/10.3904/kjim.2022.111 Text en Copyright © 2023 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cho, Young Sin
Nam, Su Youn
Moon, Hee Seok
Kim, Tae Ho
Kim, Sung Eun
Jung, Jin Tae
Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection
title Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection
title_full Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection
title_fullStr Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection
title_full_unstemmed Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection
title_short Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection
title_sort helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993100/
https://www.ncbi.nlm.nih.gov/pubmed/36437035
http://dx.doi.org/10.3904/kjim.2022.111
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