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Safety and efficacy of the feed additives 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 for animal species (FEFANA asbl)

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 (furfuryl and furan derivatives with and without additional side‐chain substituents and hete...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Brantom, Paul, Chesson, Andrew, Westendorf, Johannes, Manini, Paola, Dusemund, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993133/
https://www.ncbi.nlm.nih.gov/pubmed/36908561
http://dx.doi.org/10.2903/j.efsa.2023.7868
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Brantom, Paul
Chesson, Andrew
Westendorf, Johannes
Manini, Paola
Dusemund, Birgit
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Brantom, Paul
Chesson, Andrew
Westendorf, Johannes
Manini, Paola
Dusemund, Birgit
collection PubMed
description Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 (furfuryl and furan derivatives with and without additional side‐chain substituents and heteroatoms), when used as sensory additives (flavourings) in feed for all animal species. 2‐Acetylfuran [13.054] was tested in tolerance studies in chickens for fattening, weaned piglets and cattle for fattening. No adverse effects were observed in the tolerance studies at 10‐fold the intended use level. The FEEDAP Panel concluded that 2‐acetylfuran [13.054] is safe for these species at the proposed use level of 0.5 mg/kg and conclusions were extrapolated to all animal species. For 2‐pentylfuran [13.059], the Panel concluded that it is safe at the proposed maximum use level in feed of 0.5 mg/kg. No safety concern would arise for the consumer from the use of 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] up to the proposed maximum use level in feed as flavourings. The additives should be considered as irritant to skin and eyes and the respiratory tract, and as dermal and respiratory sensitisers. The use of 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] as flavours in animal feed was not expected to pose a risk for the environment. Since the compounds under assessment are used in food as flavourings and their function in feed is essentially the same as that in food, no further demonstration of efficacy was considered necessary.
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spelling pubmed-99931332023-03-09 Safety and efficacy of the feed additives 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 for animal species (FEFANA asbl) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Brantom, Paul Chesson, Andrew Westendorf, Johannes Manini, Paola Dusemund, Birgit EFSA J Scientific Opinion Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 (furfuryl and furan derivatives with and without additional side‐chain substituents and heteroatoms), when used as sensory additives (flavourings) in feed for all animal species. 2‐Acetylfuran [13.054] was tested in tolerance studies in chickens for fattening, weaned piglets and cattle for fattening. No adverse effects were observed in the tolerance studies at 10‐fold the intended use level. The FEEDAP Panel concluded that 2‐acetylfuran [13.054] is safe for these species at the proposed use level of 0.5 mg/kg and conclusions were extrapolated to all animal species. For 2‐pentylfuran [13.059], the Panel concluded that it is safe at the proposed maximum use level in feed of 0.5 mg/kg. No safety concern would arise for the consumer from the use of 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] up to the proposed maximum use level in feed as flavourings. The additives should be considered as irritant to skin and eyes and the respiratory tract, and as dermal and respiratory sensitisers. The use of 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] as flavours in animal feed was not expected to pose a risk for the environment. Since the compounds under assessment are used in food as flavourings and their function in feed is essentially the same as that in food, no further demonstration of efficacy was considered necessary. John Wiley and Sons Inc. 2023-03-08 /pmc/articles/PMC9993133/ /pubmed/36908561 http://dx.doi.org/10.2903/j.efsa.2023.7868 Text en © 2023 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Brantom, Paul
Chesson, Andrew
Westendorf, Johannes
Manini, Paola
Dusemund, Birgit
Safety and efficacy of the feed additives 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 for animal species (FEFANA asbl)
title Safety and efficacy of the feed additives 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 for animal species (FEFANA asbl)
title_full Safety and efficacy of the feed additives 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 for animal species (FEFANA asbl)
title_fullStr Safety and efficacy of the feed additives 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 for animal species (FEFANA asbl)
title_full_unstemmed Safety and efficacy of the feed additives 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 for animal species (FEFANA asbl)
title_short Safety and efficacy of the feed additives 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 for animal species (FEFANA asbl)
title_sort safety and efficacy of the feed additives 2‐acetylfuran [13.054] and 2‐pentylfuran [13.059] belonging to chemical group 14 for animal species (fefana asbl)
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993133/
https://www.ncbi.nlm.nih.gov/pubmed/36908561
http://dx.doi.org/10.2903/j.efsa.2023.7868
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