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Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review

Cold colorectal tumors are not likely to trigger a robust immune response and tend to suppress the immune response. There may be three reasons. First, the complex tumor microenvironment of cold colorectal cancer (CRC) leads to tolerance and clearance of immunotherapy. Second, the modification and co...

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Detalles Bibliográficos
Autores principales: Ma, Shi-Xun, Li, Li, Cai, Hui, Guo, Tian-Kang, Zhang, Lei-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993140/
https://www.ncbi.nlm.nih.gov/pubmed/36908678
http://dx.doi.org/10.5306/wjco.v14.i2.81
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author Ma, Shi-Xun
Li, Li
Cai, Hui
Guo, Tian-Kang
Zhang, Lei-Sheng
author_facet Ma, Shi-Xun
Li, Li
Cai, Hui
Guo, Tian-Kang
Zhang, Lei-Sheng
author_sort Ma, Shi-Xun
collection PubMed
description Cold colorectal tumors are not likely to trigger a robust immune response and tend to suppress the immune response. There may be three reasons. First, the complex tumor microenvironment of cold colorectal cancer (CRC) leads to tolerance and clearance of immunotherapy. Second, the modification and concealment of tumor-specific targets in cold CRC cause immune escape and immune response interruption. Finally, the difference in number and function of immune cell subsets in patients with cold CRC makes them respond poorly to immunotherapy. Therefore, we can only overcome the challenges in immunotherapy of cold CRC through in-depth research and understanding the changes and mechanisms in the above three aspects of cold CRC.
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spelling pubmed-99931402023-03-09 Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review Ma, Shi-Xun Li, Li Cai, Hui Guo, Tian-Kang Zhang, Lei-Sheng World J Clin Oncol Minireviews Cold colorectal tumors are not likely to trigger a robust immune response and tend to suppress the immune response. There may be three reasons. First, the complex tumor microenvironment of cold colorectal cancer (CRC) leads to tolerance and clearance of immunotherapy. Second, the modification and concealment of tumor-specific targets in cold CRC cause immune escape and immune response interruption. Finally, the difference in number and function of immune cell subsets in patients with cold CRC makes them respond poorly to immunotherapy. Therefore, we can only overcome the challenges in immunotherapy of cold CRC through in-depth research and understanding the changes and mechanisms in the above three aspects of cold CRC. Baishideng Publishing Group Inc 2023-02-24 2023-02-24 /pmc/articles/PMC9993140/ /pubmed/36908678 http://dx.doi.org/10.5306/wjco.v14.i2.81 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Ma, Shi-Xun
Li, Li
Cai, Hui
Guo, Tian-Kang
Zhang, Lei-Sheng
Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review
title Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review
title_full Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review
title_fullStr Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review
title_full_unstemmed Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review
title_short Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review
title_sort therapeutic challenge for immunotherapy targeting cold colorectal cancer: a narrative review
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993140/
https://www.ncbi.nlm.nih.gov/pubmed/36908678
http://dx.doi.org/10.5306/wjco.v14.i2.81
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