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Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review
Cold colorectal tumors are not likely to trigger a robust immune response and tend to suppress the immune response. There may be three reasons. First, the complex tumor microenvironment of cold colorectal cancer (CRC) leads to tolerance and clearance of immunotherapy. Second, the modification and co...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993140/ https://www.ncbi.nlm.nih.gov/pubmed/36908678 http://dx.doi.org/10.5306/wjco.v14.i2.81 |
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author | Ma, Shi-Xun Li, Li Cai, Hui Guo, Tian-Kang Zhang, Lei-Sheng |
author_facet | Ma, Shi-Xun Li, Li Cai, Hui Guo, Tian-Kang Zhang, Lei-Sheng |
author_sort | Ma, Shi-Xun |
collection | PubMed |
description | Cold colorectal tumors are not likely to trigger a robust immune response and tend to suppress the immune response. There may be three reasons. First, the complex tumor microenvironment of cold colorectal cancer (CRC) leads to tolerance and clearance of immunotherapy. Second, the modification and concealment of tumor-specific targets in cold CRC cause immune escape and immune response interruption. Finally, the difference in number and function of immune cell subsets in patients with cold CRC makes them respond poorly to immunotherapy. Therefore, we can only overcome the challenges in immunotherapy of cold CRC through in-depth research and understanding the changes and mechanisms in the above three aspects of cold CRC. |
format | Online Article Text |
id | pubmed-9993140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-99931402023-03-09 Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review Ma, Shi-Xun Li, Li Cai, Hui Guo, Tian-Kang Zhang, Lei-Sheng World J Clin Oncol Minireviews Cold colorectal tumors are not likely to trigger a robust immune response and tend to suppress the immune response. There may be three reasons. First, the complex tumor microenvironment of cold colorectal cancer (CRC) leads to tolerance and clearance of immunotherapy. Second, the modification and concealment of tumor-specific targets in cold CRC cause immune escape and immune response interruption. Finally, the difference in number and function of immune cell subsets in patients with cold CRC makes them respond poorly to immunotherapy. Therefore, we can only overcome the challenges in immunotherapy of cold CRC through in-depth research and understanding the changes and mechanisms in the above three aspects of cold CRC. Baishideng Publishing Group Inc 2023-02-24 2023-02-24 /pmc/articles/PMC9993140/ /pubmed/36908678 http://dx.doi.org/10.5306/wjco.v14.i2.81 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Ma, Shi-Xun Li, Li Cai, Hui Guo, Tian-Kang Zhang, Lei-Sheng Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review |
title | Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review |
title_full | Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review |
title_fullStr | Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review |
title_full_unstemmed | Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review |
title_short | Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review |
title_sort | therapeutic challenge for immunotherapy targeting cold colorectal cancer: a narrative review |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993140/ https://www.ncbi.nlm.nih.gov/pubmed/36908678 http://dx.doi.org/10.5306/wjco.v14.i2.81 |
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