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LLPS vs. LLCPS: analogies and differences

We compare the process of Liquid–Liquid Phase Separation (LLPS) of flexible macromolecular solutions, with the Liquid–Liquid Crystalline Phase Separation (LLCPS) of semiflexible polymers and rigid filamentous colloids, which involves the formation of a liquid phase that possesses a directional align...

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Detalles Bibliográficos
Autores principales: Azzari, Paride, Mezzenga, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993225/
https://www.ncbi.nlm.nih.gov/pubmed/36806460
http://dx.doi.org/10.1039/d2sm01455f
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author Azzari, Paride
Mezzenga, Raffaele
author_facet Azzari, Paride
Mezzenga, Raffaele
author_sort Azzari, Paride
collection PubMed
description We compare the process of Liquid–Liquid Phase Separation (LLPS) of flexible macromolecular solutions, with the Liquid–Liquid Crystalline Phase Separation (LLCPS) of semiflexible polymers and rigid filamentous colloids, which involves the formation of a liquid phase that possesses a directional alignment. Although the observed phase separation follows a similar dynamic path, namely nucleation and growth or spinodal decomposition separating two phases of dilute and concentrated compositions, the underlying physics that defines the theoretical framework of LLCPS is completely different from the one of LLPS. We review the main theories that describe the phase separation processes and relying on thermodynamics and dynamical arguments, we highlight the differences and analogies between these two phase separation phenomena, attempting to clarify the inner mechanisms that regulate those two processes. A particular focus is given to metastable phases, as these intermediate states represent a key element in understanding how phase separation works.
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spelling pubmed-99932252023-03-09 LLPS vs. LLCPS: analogies and differences Azzari, Paride Mezzenga, Raffaele Soft Matter Chemistry We compare the process of Liquid–Liquid Phase Separation (LLPS) of flexible macromolecular solutions, with the Liquid–Liquid Crystalline Phase Separation (LLCPS) of semiflexible polymers and rigid filamentous colloids, which involves the formation of a liquid phase that possesses a directional alignment. Although the observed phase separation follows a similar dynamic path, namely nucleation and growth or spinodal decomposition separating two phases of dilute and concentrated compositions, the underlying physics that defines the theoretical framework of LLCPS is completely different from the one of LLPS. We review the main theories that describe the phase separation processes and relying on thermodynamics and dynamical arguments, we highlight the differences and analogies between these two phase separation phenomena, attempting to clarify the inner mechanisms that regulate those two processes. A particular focus is given to metastable phases, as these intermediate states represent a key element in understanding how phase separation works. The Royal Society of Chemistry 2023-02-14 /pmc/articles/PMC9993225/ /pubmed/36806460 http://dx.doi.org/10.1039/d2sm01455f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Azzari, Paride
Mezzenga, Raffaele
LLPS vs. LLCPS: analogies and differences
title LLPS vs. LLCPS: analogies and differences
title_full LLPS vs. LLCPS: analogies and differences
title_fullStr LLPS vs. LLCPS: analogies and differences
title_full_unstemmed LLPS vs. LLCPS: analogies and differences
title_short LLPS vs. LLCPS: analogies and differences
title_sort llps vs. llcps: analogies and differences
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993225/
https://www.ncbi.nlm.nih.gov/pubmed/36806460
http://dx.doi.org/10.1039/d2sm01455f
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