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Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus

BACKGROUND: Diabetes mellitus is a chronic and progressive endocrine disorder that may result in macro and microvascular complications. OBJECTIVE: This study assessed some biochemical analytes in Nigerians who were recently (≤ 6 months) diagnosed with Type 2 diabetes mellitus (T2DM). METHODS: 160 T2...

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Detalles Bibliográficos
Autores principales: Ekun, Oloruntoba A, Fagbemi, Oloruntoba F, Adejumo, Esther N, Ekun, Oyeronke O, Wojuade, Kehinde S, Oshundun, Folu M, Adefolaju, Florence O, Oyegbami, Sade R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993265/
https://www.ncbi.nlm.nih.gov/pubmed/36910351
http://dx.doi.org/10.4314/ahs.v22i3.31
Descripción
Sumario:BACKGROUND: Diabetes mellitus is a chronic and progressive endocrine disorder that may result in macro and microvascular complications. OBJECTIVE: This study assessed some biochemical analytes in Nigerians who were recently (≤ 6 months) diagnosed with Type 2 diabetes mellitus (T2DM). METHODS: 160 T2DM and 90 non-diabetic control participated in this study. Blood samples were collected and analyzed for Heart-type fatty acid-binding protein (HFABP), high sensitivity C-reactive protein (hs-CRP), electrolytes, lipid and renal profile parameters, glycated haemoglobin (HBA1C) and fasting blood glucose (FBG), using standard guidelines. RESULT: The body mass index (BMI) of the T2DM volunteers was higher than control (P <0.001). The lipid profile, potassium, glucose, HBA1C, urea and creatinine values were elevated (P <0.001) while estimated glomerular filtration rate (eGFR) was lower (P<0.05) in diabetes. The median HFABP and hs-CRP were raised (P <0.05) in T2DM. Positive associations existed between FBG and urea (P <0.001), Creatinine and HBAIC (P <0.001). A logistic regression analysis, shows that an increased BMI, HBA1C, FBG, Cholesterol, urea and creatinine were associated with higher odds (p<0.001) of cardiovascular and renal complications. CONCLUSION: Elevated hs-CRP, glycated haemoglobin, urea and creatinine among T2DM increase the odds of cardiovascular and renal insults in this population.