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Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus
BACKGROUND: Diabetes mellitus is a chronic and progressive endocrine disorder that may result in macro and microvascular complications. OBJECTIVE: This study assessed some biochemical analytes in Nigerians who were recently (≤ 6 months) diagnosed with Type 2 diabetes mellitus (T2DM). METHODS: 160 T2...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Makerere Medical School
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993265/ https://www.ncbi.nlm.nih.gov/pubmed/36910351 http://dx.doi.org/10.4314/ahs.v22i3.31 |
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author | Ekun, Oloruntoba A Fagbemi, Oloruntoba F Adejumo, Esther N Ekun, Oyeronke O Wojuade, Kehinde S Oshundun, Folu M Adefolaju, Florence O Oyegbami, Sade R |
author_facet | Ekun, Oloruntoba A Fagbemi, Oloruntoba F Adejumo, Esther N Ekun, Oyeronke O Wojuade, Kehinde S Oshundun, Folu M Adefolaju, Florence O Oyegbami, Sade R |
author_sort | Ekun, Oloruntoba A |
collection | PubMed |
description | BACKGROUND: Diabetes mellitus is a chronic and progressive endocrine disorder that may result in macro and microvascular complications. OBJECTIVE: This study assessed some biochemical analytes in Nigerians who were recently (≤ 6 months) diagnosed with Type 2 diabetes mellitus (T2DM). METHODS: 160 T2DM and 90 non-diabetic control participated in this study. Blood samples were collected and analyzed for Heart-type fatty acid-binding protein (HFABP), high sensitivity C-reactive protein (hs-CRP), electrolytes, lipid and renal profile parameters, glycated haemoglobin (HBA1C) and fasting blood glucose (FBG), using standard guidelines. RESULT: The body mass index (BMI) of the T2DM volunteers was higher than control (P <0.001). The lipid profile, potassium, glucose, HBA1C, urea and creatinine values were elevated (P <0.001) while estimated glomerular filtration rate (eGFR) was lower (P<0.05) in diabetes. The median HFABP and hs-CRP were raised (P <0.05) in T2DM. Positive associations existed between FBG and urea (P <0.001), Creatinine and HBAIC (P <0.001). A logistic regression analysis, shows that an increased BMI, HBA1C, FBG, Cholesterol, urea and creatinine were associated with higher odds (p<0.001) of cardiovascular and renal complications. CONCLUSION: Elevated hs-CRP, glycated haemoglobin, urea and creatinine among T2DM increase the odds of cardiovascular and renal insults in this population. |
format | Online Article Text |
id | pubmed-9993265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Makerere Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-99932652023-03-09 Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus Ekun, Oloruntoba A Fagbemi, Oloruntoba F Adejumo, Esther N Ekun, Oyeronke O Wojuade, Kehinde S Oshundun, Folu M Adefolaju, Florence O Oyegbami, Sade R Afr Health Sci Articles BACKGROUND: Diabetes mellitus is a chronic and progressive endocrine disorder that may result in macro and microvascular complications. OBJECTIVE: This study assessed some biochemical analytes in Nigerians who were recently (≤ 6 months) diagnosed with Type 2 diabetes mellitus (T2DM). METHODS: 160 T2DM and 90 non-diabetic control participated in this study. Blood samples were collected and analyzed for Heart-type fatty acid-binding protein (HFABP), high sensitivity C-reactive protein (hs-CRP), electrolytes, lipid and renal profile parameters, glycated haemoglobin (HBA1C) and fasting blood glucose (FBG), using standard guidelines. RESULT: The body mass index (BMI) of the T2DM volunteers was higher than control (P <0.001). The lipid profile, potassium, glucose, HBA1C, urea and creatinine values were elevated (P <0.001) while estimated glomerular filtration rate (eGFR) was lower (P<0.05) in diabetes. The median HFABP and hs-CRP were raised (P <0.05) in T2DM. Positive associations existed between FBG and urea (P <0.001), Creatinine and HBAIC (P <0.001). A logistic regression analysis, shows that an increased BMI, HBA1C, FBG, Cholesterol, urea and creatinine were associated with higher odds (p<0.001) of cardiovascular and renal complications. CONCLUSION: Elevated hs-CRP, glycated haemoglobin, urea and creatinine among T2DM increase the odds of cardiovascular and renal insults in this population. Makerere Medical School 2022-09 /pmc/articles/PMC9993265/ /pubmed/36910351 http://dx.doi.org/10.4314/ahs.v22i3.31 Text en © 2022 Ekun OA et al. https://creativecommons.org/licenses/by/4.0/Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Ekun, Oloruntoba A Fagbemi, Oloruntoba F Adejumo, Esther N Ekun, Oyeronke O Wojuade, Kehinde S Oshundun, Folu M Adefolaju, Florence O Oyegbami, Sade R Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus |
title | Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus |
title_full | Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus |
title_fullStr | Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus |
title_full_unstemmed | Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus |
title_short | Assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult Nigerians recently diagnosed with type 2 diabetes mellitus |
title_sort | assessment of electrolytes, markers of glycaemic control and renal dysfunction among adult nigerians recently diagnosed with type 2 diabetes mellitus |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993265/ https://www.ncbi.nlm.nih.gov/pubmed/36910351 http://dx.doi.org/10.4314/ahs.v22i3.31 |
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