Cargando…

Controlling the crystal structure of succinic acid via microfluidic spray-drying

Many properties of materials, including their dissolution kinetics, hardness, and optical appearance, depend on their structure. Unfortunately, it is often difficult to control the structure of low molecular weight organic compounds that have a high propensity to crystallize if they are formulated f...

Descripción completa

Detalles Bibliográficos
Autores principales: Okur, Aysu Ceren, Erni, Philipp, Ouali, Lahoussine, Benczedi, Daniel, Amstad, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993402/
https://www.ncbi.nlm.nih.gov/pubmed/36909742
http://dx.doi.org/10.1039/d2ra06380h
_version_ 1784902523925037056
author Okur, Aysu Ceren
Erni, Philipp
Ouali, Lahoussine
Benczedi, Daniel
Amstad, Esther
author_facet Okur, Aysu Ceren
Erni, Philipp
Ouali, Lahoussine
Benczedi, Daniel
Amstad, Esther
author_sort Okur, Aysu Ceren
collection PubMed
description Many properties of materials, including their dissolution kinetics, hardness, and optical appearance, depend on their structure. Unfortunately, it is often difficult to control the structure of low molecular weight organic compounds that have a high propensity to crystallize if they are formulated from solutions wherein they have a high mobility. This limitation can be overcome by formulating these compounds within small airborne drops that rapidly dry, thereby limiting the time molecules have to arrange into the thermodynamically most stable phase. Such drops can be formed with a surface acoustic wave (SAW)-based spray-drier. In this paper, we demonstrate that the structure of a model low molecular weight compound relevant to applications in pharmacology and food, succinic acid, can be readily controlled with the supersaturation rate. Succinic acid particles preserve the metastable structure over at least 3 months if the initial succinic acid concentration is below 2% of its saturation concentration such that the supersaturation rate is high. We demonstrate that also the stability of the metastable phases against their transformation into the most stable phase increases with decreasing initial solute concentration and hence with increasing supersaturation rate of the spray-dried solution. These insights open up new opportunities to control the crystal structure and therefore properties of low molecular weight compounds that have a high propensity to crystallize.
format Online
Article
Text
id pubmed-9993402
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-99934022023-03-09 Controlling the crystal structure of succinic acid via microfluidic spray-drying Okur, Aysu Ceren Erni, Philipp Ouali, Lahoussine Benczedi, Daniel Amstad, Esther RSC Adv Chemistry Many properties of materials, including their dissolution kinetics, hardness, and optical appearance, depend on their structure. Unfortunately, it is often difficult to control the structure of low molecular weight organic compounds that have a high propensity to crystallize if they are formulated from solutions wherein they have a high mobility. This limitation can be overcome by formulating these compounds within small airborne drops that rapidly dry, thereby limiting the time molecules have to arrange into the thermodynamically most stable phase. Such drops can be formed with a surface acoustic wave (SAW)-based spray-drier. In this paper, we demonstrate that the structure of a model low molecular weight compound relevant to applications in pharmacology and food, succinic acid, can be readily controlled with the supersaturation rate. Succinic acid particles preserve the metastable structure over at least 3 months if the initial succinic acid concentration is below 2% of its saturation concentration such that the supersaturation rate is high. We demonstrate that also the stability of the metastable phases against their transformation into the most stable phase increases with decreasing initial solute concentration and hence with increasing supersaturation rate of the spray-dried solution. These insights open up new opportunities to control the crystal structure and therefore properties of low molecular weight compounds that have a high propensity to crystallize. The Royal Society of Chemistry 2023-03-08 /pmc/articles/PMC9993402/ /pubmed/36909742 http://dx.doi.org/10.1039/d2ra06380h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Okur, Aysu Ceren
Erni, Philipp
Ouali, Lahoussine
Benczedi, Daniel
Amstad, Esther
Controlling the crystal structure of succinic acid via microfluidic spray-drying
title Controlling the crystal structure of succinic acid via microfluidic spray-drying
title_full Controlling the crystal structure of succinic acid via microfluidic spray-drying
title_fullStr Controlling the crystal structure of succinic acid via microfluidic spray-drying
title_full_unstemmed Controlling the crystal structure of succinic acid via microfluidic spray-drying
title_short Controlling the crystal structure of succinic acid via microfluidic spray-drying
title_sort controlling the crystal structure of succinic acid via microfluidic spray-drying
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993402/
https://www.ncbi.nlm.nih.gov/pubmed/36909742
http://dx.doi.org/10.1039/d2ra06380h
work_keys_str_mv AT okuraysuceren controllingthecrystalstructureofsuccinicacidviamicrofluidicspraydrying
AT erniphilipp controllingthecrystalstructureofsuccinicacidviamicrofluidicspraydrying
AT oualilahoussine controllingthecrystalstructureofsuccinicacidviamicrofluidicspraydrying
AT benczedidaniel controllingthecrystalstructureofsuccinicacidviamicrofluidicspraydrying
AT amstadesther controllingthecrystalstructureofsuccinicacidviamicrofluidicspraydrying