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Assessment of Choroidal Vascularity in Inactive Thyroid Associated Orbitopathy

OBJECTIVES: The objectives of the study were to evaluate the vascular and stromal structure of the choroid in patients with inactive thyroid associated orbitopathy (TAO) by measuring choroidal vascularity index (CVI) and choroidal thickness (CT) using enhanced depth imaging (EDI) optical coherence t...

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Autores principales: Pehlivanoglu, Seren, Aksoy, Funda Ebru, Karabulut, Gamze Ozturk, Tunc, Ugur, Fazil, Korhan, Artunay, Ozgur, Taskapili, Muhittin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993418/
https://www.ncbi.nlm.nih.gov/pubmed/36911212
http://dx.doi.org/10.14744/bej.2022.04900
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author Pehlivanoglu, Seren
Aksoy, Funda Ebru
Karabulut, Gamze Ozturk
Tunc, Ugur
Fazil, Korhan
Artunay, Ozgur
Taskapili, Muhittin
author_facet Pehlivanoglu, Seren
Aksoy, Funda Ebru
Karabulut, Gamze Ozturk
Tunc, Ugur
Fazil, Korhan
Artunay, Ozgur
Taskapili, Muhittin
author_sort Pehlivanoglu, Seren
collection PubMed
description OBJECTIVES: The objectives of the study were to evaluate the vascular and stromal structure of the choroid in patients with inactive thyroid associated orbitopathy (TAO) by measuring choroidal vascularity index (CVI) and choroidal thickness (CT) using enhanced depth imaging (EDI) optical coherence tomography (OCT). METHODS: The choroidal image was taken with EDI mode spectral domain (SD)-OCT. All scans were taken between 9.30 am and 11.30 am to avoid the diurnal variation of CT and CVI. To calculate CVI, macular SD-OCT scans were binarized using the publicly available software ImageJ and luminal area and total choroidal area (TCA) were measured. CVI was calculated as the proportion of LA to TCA. Furthermore, the relation between CVI and axial length, gender, and age was evaluated. RESULTS: This study included 78 individuals with a mean age of 51.4±7.3 years. Group 1 consisted of 44 patients with inactive stage TAO, and Group 2 consisted of 34 healthy controls. Subfoveal CT was 338.92±73.93 µm in Group 1 and 303.97±40.35 µm in Group 2 (p=0.174). The CVI significantly differed between the two groups, which was higher in group 1 (p=0.000). CONCLUSION: Although CT was not different between groups, CVI which is the indicator of the vascular status of the choroid, was higher in patients with TAO in the inactive stage compared with healthy control subjects.
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spelling pubmed-99934182023-03-09 Assessment of Choroidal Vascularity in Inactive Thyroid Associated Orbitopathy Pehlivanoglu, Seren Aksoy, Funda Ebru Karabulut, Gamze Ozturk Tunc, Ugur Fazil, Korhan Artunay, Ozgur Taskapili, Muhittin Beyoglu Eye J Original Article OBJECTIVES: The objectives of the study were to evaluate the vascular and stromal structure of the choroid in patients with inactive thyroid associated orbitopathy (TAO) by measuring choroidal vascularity index (CVI) and choroidal thickness (CT) using enhanced depth imaging (EDI) optical coherence tomography (OCT). METHODS: The choroidal image was taken with EDI mode spectral domain (SD)-OCT. All scans were taken between 9.30 am and 11.30 am to avoid the diurnal variation of CT and CVI. To calculate CVI, macular SD-OCT scans were binarized using the publicly available software ImageJ and luminal area and total choroidal area (TCA) were measured. CVI was calculated as the proportion of LA to TCA. Furthermore, the relation between CVI and axial length, gender, and age was evaluated. RESULTS: This study included 78 individuals with a mean age of 51.4±7.3 years. Group 1 consisted of 44 patients with inactive stage TAO, and Group 2 consisted of 34 healthy controls. Subfoveal CT was 338.92±73.93 µm in Group 1 and 303.97±40.35 µm in Group 2 (p=0.174). The CVI significantly differed between the two groups, which was higher in group 1 (p=0.000). CONCLUSION: Although CT was not different between groups, CVI which is the indicator of the vascular status of the choroid, was higher in patients with TAO in the inactive stage compared with healthy control subjects. Kare Publishing 2023-03-01 /pmc/articles/PMC9993418/ /pubmed/36911212 http://dx.doi.org/10.14744/bej.2022.04900 Text en Copyright: © 2023 by Beyoglu Eye Training and Research Hospital https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Article
Pehlivanoglu, Seren
Aksoy, Funda Ebru
Karabulut, Gamze Ozturk
Tunc, Ugur
Fazil, Korhan
Artunay, Ozgur
Taskapili, Muhittin
Assessment of Choroidal Vascularity in Inactive Thyroid Associated Orbitopathy
title Assessment of Choroidal Vascularity in Inactive Thyroid Associated Orbitopathy
title_full Assessment of Choroidal Vascularity in Inactive Thyroid Associated Orbitopathy
title_fullStr Assessment of Choroidal Vascularity in Inactive Thyroid Associated Orbitopathy
title_full_unstemmed Assessment of Choroidal Vascularity in Inactive Thyroid Associated Orbitopathy
title_short Assessment of Choroidal Vascularity in Inactive Thyroid Associated Orbitopathy
title_sort assessment of choroidal vascularity in inactive thyroid associated orbitopathy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993418/
https://www.ncbi.nlm.nih.gov/pubmed/36911212
http://dx.doi.org/10.14744/bej.2022.04900
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