A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models

Spleen tyrosine kinase (Syk) plays a pivotal role in the activation of B cells and innate inflammatory cells by transducing immune receptor-triggered signals. Dysregulated activity of Syk is implicated in the development of antibody-mediated autoimmune diseases including systemic lupus erythematosus...

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Detalles Bibliográficos
Autores principales: Cho, Somi, Jang, Eunkyeong, Yoon, Taeyoung, Hwang, Haejun, Youn, Jeehee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Autoimmunity/Autoimmune Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993459/
https://www.ncbi.nlm.nih.gov/pubmed/36346114
http://dx.doi.org/10.1093/cei/uxac096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993459/
https://www.ncbi.nlm.nih.gov/pubmed/36346114
http://dx.doi.org/10.1093/cei/uxac096

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