Cargando…

A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models

Spleen tyrosine kinase (Syk) plays a pivotal role in the activation of B cells and innate inflammatory cells by transducing immune receptor-triggered signals. Dysregulated activity of Syk is implicated in the development of antibody-mediated autoimmune diseases including systemic lupus erythematosus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cho, Somi, Jang, Eunkyeong, Yoon, Taeyoung, Hwang, Haejun, Youn, Jeehee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Autoimmunity/Autoimmune Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993459/ https://www.ncbi.nlm.nih.gov/pubmed/36346114 http://dx.doi.org/10.1093/cei/uxac096

Ejemplares similares

S307: CEVIDOPLENIB (SKI-O-703), A NOVEL SYK INHIBITOR, REDUCES ANTIPHOSPHOLIPID ANTIBODY TITERS AND PREVENTS INTRAMYOCARDIAL SMALL ARTERIAL THROMBOSIS IN A MOUSE MODEL OF ANTIPHOSPHOLIPID SYNDROME
por: Jang, Eunkyeong, et al.
Publicado: (2023)

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1
por: Nanda, Sambit K., et al.
Publicado: (2016)

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity
por: Hodgson, Rose, et al.
Publicado: (2023)

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice
por: Sood, Shatakshi, et al.
Publicado: (2016)

Rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren’s syndrome shared megakaryocyte expansion in peripheral blood
por: Wang, Yukai, et al.
Publicado: (2022)

A novel monoclonal antibody with improved FcγR blocking ability demonstrated non-inferior efficacy compared to IVIG in cynomolgus monkey ITP model at considerably lower dose
por: Nakajima-Kato, Yuko, et al.
Publicado: (2022)

Tofacitinib treatment modulates the levels of several inflammation-related plasma proteins in rheumatoid arthritis and baseline levels of soluble biomarkers associate with the treatment response
por: Valli, Atte, et al.
Publicado: (2022)

The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic variants
por: Williams, C L, et al.
Publicado: (2022)

Combination therapy of a TRPV2 agonist with a TNF inhibitor achieves sustained suppression of disease severity and reduced joint damage
por: Laragione, Teresina, et al.
Publicado: (2022)

CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients
por: Vandewalle, Julie, et al.
Publicado: (2023)

Diagnostic markers and potential therapeutic agents for Sjögren’s syndrome screened through multiple machine learning and molecular docking
por: Zhou, Liqing, et al.
Publicado: (2023)

The Lupus‐Associated Fcγ Receptor IIb–I232T Polymorphism Results in Impairment in the Negative Selection of Low‐Affinity Germinal Center B Cells Via c‐Abl in Mice
por: Jhou, Jyun‐Pei, et al.
Publicado: (2018)

Development of a Conceptual Model to Understand Disease Burden in Patients With Systemic Lupus Erythematosus and Organ Damage
por: Broderick, Lynne, et al.
Publicado: (2023)

Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis
por: Giles, Joanna L., et al.
Publicado: (2015)

Cancer immunotherapy-induced rheumatic diseases emerge as new clinical entities
por: Cappelli, Laura C, et al.
Publicado: (2016)

Tissue-Resident Exhausted Effector Memory CD8(+) T Cells Accumulate in the Retina during Chronic Experimental Autoimmune Uveoretinitis
por: Boldison, Joanne, et al.
Publicado: (2014)

Characteristics and treatment of new-onset arthritis after checkpoint inhibitor therapy
por: Leipe, Jan, et al.
Publicado: (2018)

Distinct features distinguishing IgG4-related disease from multicentric Castleman’s disease
por: Sasaki, Takanori, et al.
Publicado: (2017)

Antiphospholipid syndrome: state of the art on clinical practice guidelines
por: Limper, Marteen, et al.
Publicado: (2018)

Automated evaluation of ANA under real-life conditions
por: Loock, Clemens Dario, et al.
Publicado: (2017)

Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity
por: Roberts, Natalie A., et al.
Publicado: (2017)

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology
por: Brucklacher-Waldert, Verena, et al.
Publicado: (2016)

Rheumatic immune-related adverse events of checkpoint therapy for cancer: case series of a new nosological entity
por: Calabrese, C, et al.
Publicado: (2017)

Recognising the spectrum of scleromyositis: HEp-2 ANA patterns allow identification of a novel clinical subset with anti-SMN autoantibodies
por: Landon-Cardinal, Océane, et al.
Publicado: (2020)

Systemic Autoimmune Disease Among Adults Exposed to the September 11, 2001 Terrorist Attack
por: Miller‐Archie, Sara A., et al.
Publicado: (2020)

Efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases: a systematic literature review for the 2019 update of EULAR recommendations
por: Rondaan, Christien, et al.
Publicado: (2019)

Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a systematic literature research
por: Kerschbaumer, Andreas, et al.
Publicado: (2020)

Point of view on the vaccination against COVID-19 in patients with autoimmune inflammatory rheumatic diseases
por: Furer, Victoria, et al.
Publicado: (2021)

Inflammaging as a link between autoimmunity and cardiovascular disease: the case of rheumatoid arthritis
por: Santos-Moreno, Pedro, et al.
Publicado: (2021)

Current status of use of high throughput nucleotide sequencing in rheumatology
por: Boegel, Sebastian, et al.
Publicado: (2021)

Association between T follicular helper cells and T peripheral helper cells with B-cell biomarkers and disease activity in primary Sjögren syndrome
por: Dupré, Anastasia, et al.
Publicado: (2021)

Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease
por: Tomofuji, Yoshihiko, et al.
Publicado: (2022)

Association between long-term exposure to air pollution and immune-mediated diseases: a population-based cohort study
por: Adami, Giovanni, et al.
Publicado: (2022)

Direct oral anticoagulants versus vitamin K antagonists in patients with antiphospholipid syndrome: systematic review and meta-analysis
por: Koval, Nazariy, et al.
Publicado: (2021)

A systematic literature review informing the consensus statement on efficacy and safety of pharmacological treatment with interleukin-6 pathway inhibition with biological DMARDs in immune-mediated inflammatory diseases
por: Kastrati, Kastriot, et al.
Publicado: (2022)

Immune-mediated inflammatory diseases after anti-SARS-CoV-2 vaccines: new diagnoses and disease flares
por: Carubbi, Francesco, et al.
Publicado: (2022)

Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component
por: Shirai, Yuya, et al.
Publicado: (2022)

Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis
por: Yan, Songxin, et al.
Publicado: (2022)

Machine Learning for the Identification of a Common Signature for Anti–SSA/Ro 60 Antibody Expression Across Autoimmune Diseases
por: Foulquier, Nathan, et al.
Publicado: (2022)

Tolerance and efficacy of targeted therapies prescribed for off-label indications in refractory systemic autoimmune diseases: data of the first 100 patients enrolled in the TATA registry (TArgeted Therapy in Autoimmune Diseases)
por: Gottenberg, Jacques-Eric, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h7tq39q6ils991e2m146sqemmd