Liver Metastasis Modulate Responses of Suppressive Macrophages and Exhausted T Cells to Immunotherapy Revealed by Single Cell Sequencing

Liver metastasis is associated with immunotherapy resistance, although the underlying mechanisms remain incompletely understood. By applying single cell RNA‐sequencing to a concurrent subcutaneous and liver tumor murine model to recapitulate liver metastases, it is identified that subsets within tum...

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Detalles Bibliográficos
Autores principales: Zhang, Qiming, Liu, Siyuan, Liu, Yedan, Bhatt, Dev, Estrada, Juan, Belmontes, Brian, Ren, Xianwen, Canon, Jude, Ouyang, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993474/
https://www.ncbi.nlm.nih.gov/pubmed/36911291
http://dx.doi.org/10.1002/ggn2.202200002

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