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Physical activity levels in cognitively normal and cognitively impaired oldest-old and the association with dementia risk factors: a pilot study
BACKGROUND: Research assessing the relationship of physical activity and dementia is usually based on studies with individuals younger than 90 years of age. The primary aim of this study was to determine physical activity levels of cognitively normal and cognitively impaired adults older than 90 yea...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993554/ https://www.ncbi.nlm.nih.gov/pubmed/36882690 http://dx.doi.org/10.1186/s12877-023-03814-4 |
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author | Muurling, Marijn Badissi, Maryam de Boer, Casper Legdeur, Nienke Barkhof, Frederik van Berckel, Bart N.M. Maier, Andrea B. Pijnappels, Mirjam Visser, Pieter Jelle |
author_facet | Muurling, Marijn Badissi, Maryam de Boer, Casper Legdeur, Nienke Barkhof, Frederik van Berckel, Bart N.M. Maier, Andrea B. Pijnappels, Mirjam Visser, Pieter Jelle |
author_sort | Muurling, Marijn |
collection | PubMed |
description | BACKGROUND: Research assessing the relationship of physical activity and dementia is usually based on studies with individuals younger than 90 years of age. The primary aim of this study was to determine physical activity levels of cognitively normal and cognitively impaired adults older than 90 years of age (oldest-old). Our secondary aim was to assess if physical activity is associated with risk factors for dementia and brain pathology biomarkers. METHODS: Physical activity was assessed in cognitively normal (N = 49) and cognitively impaired (N = 12) oldest-old by trunk accelerometry for a 7-day period. We tested physical performance parameters and nutritional status as dementia risk factors, and brain pathology biomarkers. Linear regression models were used to examine the associations, correcting for age, sex and years of education. RESULTS: Cognitively normal oldest-old were on average active for a total duration of 45 (SD 27) minutes per day, while cognitively impaired oldest-old seemed less physically active with 33 (SD 21) minutes per day with a lower movement intensity. Higher active duration and lower sedentary duration were related to better nutritional status and better physical performance. Higher movement intensities were related to better nutritional status, better physical performance and less white matter hyperintensities. Longer maximum walking bout duration associated with more amyloid binding. CONCLUSION: We found that cognitively impaired oldest-old are active at a lower movement intensity than cognitively normal oldest-old individuals. In the oldest-old, physical activity is related to physical parameters, nutritional status, and moderately to brain pathology biomarkers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-023-03814-4. |
format | Online Article Text |
id | pubmed-9993554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99935542023-03-09 Physical activity levels in cognitively normal and cognitively impaired oldest-old and the association with dementia risk factors: a pilot study Muurling, Marijn Badissi, Maryam de Boer, Casper Legdeur, Nienke Barkhof, Frederik van Berckel, Bart N.M. Maier, Andrea B. Pijnappels, Mirjam Visser, Pieter Jelle BMC Geriatr Research BACKGROUND: Research assessing the relationship of physical activity and dementia is usually based on studies with individuals younger than 90 years of age. The primary aim of this study was to determine physical activity levels of cognitively normal and cognitively impaired adults older than 90 years of age (oldest-old). Our secondary aim was to assess if physical activity is associated with risk factors for dementia and brain pathology biomarkers. METHODS: Physical activity was assessed in cognitively normal (N = 49) and cognitively impaired (N = 12) oldest-old by trunk accelerometry for a 7-day period. We tested physical performance parameters and nutritional status as dementia risk factors, and brain pathology biomarkers. Linear regression models were used to examine the associations, correcting for age, sex and years of education. RESULTS: Cognitively normal oldest-old were on average active for a total duration of 45 (SD 27) minutes per day, while cognitively impaired oldest-old seemed less physically active with 33 (SD 21) minutes per day with a lower movement intensity. Higher active duration and lower sedentary duration were related to better nutritional status and better physical performance. Higher movement intensities were related to better nutritional status, better physical performance and less white matter hyperintensities. Longer maximum walking bout duration associated with more amyloid binding. CONCLUSION: We found that cognitively impaired oldest-old are active at a lower movement intensity than cognitively normal oldest-old individuals. In the oldest-old, physical activity is related to physical parameters, nutritional status, and moderately to brain pathology biomarkers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-023-03814-4. BioMed Central 2023-03-07 /pmc/articles/PMC9993554/ /pubmed/36882690 http://dx.doi.org/10.1186/s12877-023-03814-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Muurling, Marijn Badissi, Maryam de Boer, Casper Legdeur, Nienke Barkhof, Frederik van Berckel, Bart N.M. Maier, Andrea B. Pijnappels, Mirjam Visser, Pieter Jelle Physical activity levels in cognitively normal and cognitively impaired oldest-old and the association with dementia risk factors: a pilot study |
title | Physical activity levels in cognitively normal and cognitively impaired oldest-old and the association with dementia risk factors: a pilot study |
title_full | Physical activity levels in cognitively normal and cognitively impaired oldest-old and the association with dementia risk factors: a pilot study |
title_fullStr | Physical activity levels in cognitively normal and cognitively impaired oldest-old and the association with dementia risk factors: a pilot study |
title_full_unstemmed | Physical activity levels in cognitively normal and cognitively impaired oldest-old and the association with dementia risk factors: a pilot study |
title_short | Physical activity levels in cognitively normal and cognitively impaired oldest-old and the association with dementia risk factors: a pilot study |
title_sort | physical activity levels in cognitively normal and cognitively impaired oldest-old and the association with dementia risk factors: a pilot study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993554/ https://www.ncbi.nlm.nih.gov/pubmed/36882690 http://dx.doi.org/10.1186/s12877-023-03814-4 |
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