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Dearomative intermolecular [2 + 2] photocycloaddition for construction of C(sp(3))-rich heterospirocycles on-DNA

DNA-encoded library (DEL) screens have significantly impacted new lead compound identification efforts within drug discovery. An advantage of DELs compared to traditional screening methods is that an exponentially broader chemical space can be effectively screened using only nmol quantities of billi...

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Detalles Bibliográficos
Autores principales:	Li, Longbo, Matsuo, Bianca, Levitre, Guillaume, McClain, Edward J., Voight, Eric A., Crane, Erika A., Molander, Gary A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993886/ https://www.ncbi.nlm.nih.gov/pubmed/36908969 http://dx.doi.org/10.1039/d3sc00144j

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