Cargando…

Synthesis, analysis of molecular and crystal structures, estimation of intermolecular interactions and biological properties of 1-benzyl-6-fluoro-3-[5-(4-methylcyclohexyl)-1,2,4-oxadiazol-3-yl]-7-(piperidin-1-yl)quinolin-4-one

The title compound, C(30)H(33)N(4)O(2)F, can be obtained via a two-step synthetic scheme involving 1-benzyl-6-fluoro-4-oxo-7-(piperidin-1-yl)-1,4-dihydroquinoline-3-carbonitrile as a starting compound that undergoes substitution with hydroxylamine and subsequent cyclization with 4-methylcyclo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vaksler, Yevhenii, Hryhoriv, Halyna V., Ivanov, Vladimir V., Kovalenko, Sergiy M., Georgiyants, Victoriya A., Langer, Thierry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2023
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993923/ https://www.ncbi.nlm.nih.gov/pubmed/36910005 http://dx.doi.org/10.1107/S2056989023001305

Ejemplares similares

Synthesis, X-ray diffraction study, analysis of intermolecular interactions and molecular docking of ethyl 1-(3-tosylquinolin-4-yl)piperidine-4-carboxylate
por: Vaksler, Yevhenii, et al.
Publicado: (2022)

Three closely related 1-[(1,3-benzodioxol-5-yl)methyl]-4-(halobenzoyl)piperazines: similar molecular structures but different intermolecular interactions
por: Mahesha, Ninganayaka, et al.
Publicado: (2019)

4-[4-(Piperidin-1-yl)piperidin-1-yl]benzonitrile
por: Xu, Guo-bin, et al.
Publicado: (2010)

A Comprehensive Review on Chemical Synthesis and Chemotherapeutic Potential of 3-Heteroaryl Fluoroquinolone Hybrids
por: Hryhoriv, Halyna, et al.
Publicado: (2023)

(4-Methoxyphenyl)(4-methylcyclohexyl)methanone
por: Liu, Wei, et al.
Publicado: (2012)

4-[4-(4-Amino-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl]-1,2,5-oxadiazol-3-amine
por: Jia, Si-Yuan, et al.
Publicado: (2012)

4-{[4-(Hydroxymethyl)piperidin-1-yl]methyl}phenol
por: Simões, M. C. R., et al.
Publicado: (2012)

1-{3-[(4-Oxopiperidin-1-yl)carbonyl]benzoyl}piperidin-4-one
por: Rajesh, K., et al.
Publicado: (2010)

1,4-Bis{[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}butane
por: Liu, Qing-lei, et al.
Publicado: (2011)

(S)-tert-Butyl 3-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate
por: Liu, Lin, et al.
Publicado: (2010)

N-[(1-Benzoylpiperidin-4-yl)methyl]benzamide
por: Prathebha, K., et al.
Publicado: (2014)

Crystal structure, Hirshfeld analysis and a molecular docking study of a new inhibitor of the Hepatitis B virus (HBV): ethyl 5-methyl-1,1-dioxo-2-{[5-(pentan-3-yl)-1,2,4-oxadiazol-3-yl]methyl}-2H-1,2,6-thiadiazine-4-carboxylate
por: Ivachtchenko, Alexandre V., et al.
Publicado: (2020)

2-(Adamantan-1-yl)-5-(4-nitrophenyl)-1,3,4-oxadiazole
por: El-Emam, Ali A., et al.
Publicado: (2012)

N-[4-(4-Bromophenyl)thiazol-2-yl]-4-(piperidin-1-yl)butanamide
por: Ghabbour, Hazem A., et al.
Publicado: (2012)

Methyl 4-(piperidin-1-ylcarbonyl)benzoate
por: Ávila, R. M. D., et al.
Publicado: (2010)

4-[5-(Pyridin-4-yl)-1,3,4-oxadiazol-2-yl]pyridinium benzoate
por: Han, Meng Ting, et al.
Publicado: (2011)

1,4-Bis(piperidin-1-ylcarbonyl)benzene
por: Armbrust, Lee, et al.
Publicado: (2007)

N (1)-(4-Methylphenyl)piperidine-1,4-dicarboxamide
por: Islor, Arun M., et al.
Publicado: (2012)

Six 1-aroyl-4-(4-methoxyphenyl)piperazines: similar molecular structures but different patterns of supramolecular assembly
por: Kiran Kumar, Haruvegowda, et al.
Publicado: (2019)

Crystal structure of (4-chlorophenyl)(4-methylpiperidin-1-yl)methanone
por: Srividya, J., et al.
Publicado: (2020)

Crystal structure of 4,4′-bis[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl
por: Walbaum, Anqi, et al.
Publicado: (2017)

Crystal structure of the adduct (4-chlorophenyl)(4-hydroxypiperidin-1-yl)methanone–(4-chlorophenyl)(piperidin-1-yl)methanone (0.75/0.25)
por: Revathi, B. K., et al.
Publicado: (2015)

4-[(2-Hydroxy-1-naphthyl)(piperidin-1-yl)methyl]benzonitrile
por: Zhang, Yuan, et al.
Publicado: (2009)

1-{[5-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl]}piperidin-4-one
por: Shahani, Tara, et al.
Publicado: (2010)

2-(4-Chlorophenyl)-5-{3,4-dibutoxy-5-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]thiophen-2-yl}-1,3,4-oxadiazole
por: Li, Hai-Lin, et al.
Publicado: (2008)

Crystal structure of 4-methyl-N-{[1-(4-methylbenzoyl)piperidin-4-yl]methyl}benzamide
por: Prathebha, K., et al.
Publicado: (2014)

3-(4-Chlorobenzoyl)-4-(4-chlorophenyl)-1-phenethylpiperidin-4-ol
por: Aydın, Abdullah, et al.
Publicado: (2011)

Crystal structure of [4-(chloromethyl)phenyl](4-hydroxypiperidin-1-yl)methanone
por: Revathi, B. K., et al.
Publicado: (2015)

Comparison of the crystal structures of 4,4′-bis[3-(4-methylpiperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl and 4,4′-bis[3-(2,2,6,6-tetramethylpiperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl
por: Wan, Anqi, et al.
Publicado: (2015)

4-[3-(Chloromethyl)-1,2,4-oxadiazol-5-yl]pyridine. Corrigendum
por: Kang, Si-shun, et al.
Publicado: (2008)

Crystal structures and Hirshfeld surface analysis of 2-(adamantan-1-yl)-5-(4-fluorophenyl)-1,3,4-oxadiazole and 2-(adamantan-1-yl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2019)

Crystal structure of (4-hydroxypiperidin-1-yl)(4-methylphenyl)methanone
por: Revathi, B. K., et al.
Publicado: (2015)

Dichloridobis[3-(4-methoxyphenyl)-2-methyl-5-(piperidin-1-yl)-2,3-dihydro-1,2,4-oxadiazole-κN (4)]platinum(II)
por: Kritchenkov, Andreii S., et al.
Publicado: (2013)

N-Methacryloyl-4-(piperidin-1-yl)-1,8-naphthalimide
por: Hanton, Lyall R., et al.
Publicado: (2010)

N-Phenyl-N-{4-[5-(4-pyridyl)-1,3,4-oxadiazol-2-yl]phenyl}aniline
por: Han, Li-Ping, et al.
Publicado: (2007)

{4-[5-(4-tert-Butylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}methanol
por: Zhao, Yu-Ling, et al.
Publicado: (2011)

2,2-Diphenyl-4-(piperidin-1-yl)butanamide
por: Siddegowda, M. S., et al.
Publicado: (2011)

Crystal structure of 4-chloro-N-{[1-(4-chlorobenzoyl)piperidin-4-yl]methyl}benzamide monohydrate
por: Prathebha, K., et al.
Publicado: (2014)

2-(4-tert-Butylphenyl)-5-{3,4-dibutoxy-5-[5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl]-2-thienyl}-1,3,4-oxadiazole
por: Guan, Jian-ning, et al.
Publicado: (2008)

N-(4-Chlorophenyl)-4-methylpiperidine-1-carboxamide
por: Li, Yu-Feng
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_tq7oocvd908q2arfb56h951svo