Role of ferroptosis in colorectal cancer

Colorectal cancer (CRC) is the second deadliest cancer and the third-most common malignancy in the world. Surgery, chemotherapy, and targeted therapy have been widely used to treat CRC, but some patients still develop resistance to these treatments. Ferroptosis is a novel non-apoptotic form of cell...

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Autores principales: Song, Ya-Qi, Yan, Xiao-Dan, Wang, Yi, Wang, Zhen-Zhen, Mao, Xin-Li, Ye, Li-Ping, Li, Shao-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994046/
https://www.ncbi.nlm.nih.gov/pubmed/36908317
http://dx.doi.org/10.4251/wjgo.v15.i2.225
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author Song, Ya-Qi
Yan, Xiao-Dan
Wang, Yi
Wang, Zhen-Zhen
Mao, Xin-Li
Ye, Li-Ping
Li, Shao-Wei
author_facet Song, Ya-Qi
Yan, Xiao-Dan
Wang, Yi
Wang, Zhen-Zhen
Mao, Xin-Li
Ye, Li-Ping
Li, Shao-Wei
author_sort Song, Ya-Qi
collection PubMed
description Colorectal cancer (CRC) is the second deadliest cancer and the third-most common malignancy in the world. Surgery, chemotherapy, and targeted therapy have been widely used to treat CRC, but some patients still develop resistance to these treatments. Ferroptosis is a novel non-apoptotic form of cell death. It is an iron-dependent non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species and has been suggested to play a role in reversing resistance to anticancer drugs. This review summarizes recent advances in the prognostic role of ferroptosis in CRC and the mechanism of action in CRC.
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spelling pubmed-99940462023-03-09 Role of ferroptosis in colorectal cancer Song, Ya-Qi Yan, Xiao-Dan Wang, Yi Wang, Zhen-Zhen Mao, Xin-Li Ye, Li-Ping Li, Shao-Wei World J Gastrointest Oncol Review Colorectal cancer (CRC) is the second deadliest cancer and the third-most common malignancy in the world. Surgery, chemotherapy, and targeted therapy have been widely used to treat CRC, but some patients still develop resistance to these treatments. Ferroptosis is a novel non-apoptotic form of cell death. It is an iron-dependent non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species and has been suggested to play a role in reversing resistance to anticancer drugs. This review summarizes recent advances in the prognostic role of ferroptosis in CRC and the mechanism of action in CRC. Baishideng Publishing Group Inc 2023-02-15 2023-02-15 /pmc/articles/PMC9994046/ /pubmed/36908317 http://dx.doi.org/10.4251/wjgo.v15.i2.225 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Song, Ya-Qi
Yan, Xiao-Dan
Wang, Yi
Wang, Zhen-Zhen
Mao, Xin-Li
Ye, Li-Ping
Li, Shao-Wei
Role of ferroptosis in colorectal cancer
title Role of ferroptosis in colorectal cancer
title_full Role of ferroptosis in colorectal cancer
title_fullStr Role of ferroptosis in colorectal cancer
title_full_unstemmed Role of ferroptosis in colorectal cancer
title_short Role of ferroptosis in colorectal cancer
title_sort role of ferroptosis in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994046/
https://www.ncbi.nlm.nih.gov/pubmed/36908317
http://dx.doi.org/10.4251/wjgo.v15.i2.225
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AT maoxinli roleofferroptosisincolorectalcancer
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