Cryo-EM structure of the RADAR supramolecular anti-phage defense complex

RADAR is a two-protein bacterial defense system that was reported to defend against phage by “editing” messenger RNA. Here, we determine cryo-EM structures of the RADAR defense complex, revealing RdrA as a heptameric, two-layered AAA+ ATPase and RdrB as a dodecameric, hollow complex with twelve surf...

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Detalles Bibliográficos
Autores principales: Duncan-Lowey, Brianna, Tal, Nitzan, Johnson, Alex G., Rawson, Shaun, Mayer, Megan L., Doron, Shany, Millman, Adi, Melamed, Sarah, Fedorenko, Taya, Kacen, Assaf, Brandis, Alexander, Mehlman, Tevie, Amitai, Gil, Sorek, Rotem, Kranzusch, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994260/
https://www.ncbi.nlm.nih.gov/pubmed/36764290
http://dx.doi.org/10.1016/j.cell.2023.01.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994260/
https://www.ncbi.nlm.nih.gov/pubmed/36764290
http://dx.doi.org/10.1016/j.cell.2023.01.012

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