Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents

The emergence of drug-resistant tuberculosis has created an urgent need for new anti-tubercular agents. Here, we report the discovery of a series of macrolides called sequanamycins with outstanding in vitro and in vivo activity against Mycobacterium tuberculosis (Mtb). Sequanamycins are bacterial ri...

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Detalles Bibliográficos
Autores principales: Zhang, Jidong, Lair, Christine, Roubert, Christine, Amaning, Kwame, Barrio, María Belén, Benedetti, Yannick, Cui, Zhicheng, Xing, Zhongliang, Li, Xiaojun, Franzblau, Scott G., Baurin, Nicolas, Bordon-Pallier, Florence, Cantalloube, Cathy, Sans, Stephanie, Silve, Sandra, Blanc, Isabelle, Fraisse, Laurent, Rak, Alexey, Jenner, Lasse B., Yusupova, Gulnara, Yusupov, Marat, Zhang, Junjie, Kaneko, Takushi, Yang, T.J., Fotouhi, Nader, Nuermberger, Eric, Tyagi, Sandeep, Betoudji, Fabrice, Upton, Anna, Sacchettini, James C., Lagrange, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994261/
https://www.ncbi.nlm.nih.gov/pubmed/36827973
http://dx.doi.org/10.1016/j.cell.2023.01.043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994261/
https://www.ncbi.nlm.nih.gov/pubmed/36827973
http://dx.doi.org/10.1016/j.cell.2023.01.043

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