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The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells
Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994688/ https://www.ncbi.nlm.nih.gov/pubmed/36888604 http://dx.doi.org/10.1371/journal.pone.0282347 |
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author | Bhattacharya, Shreya Maupin, Alec Jacob Schlosser, Anders Grønnegaard Füchtbauer, Ernst-Martin Gloria, Yamel Cardona Weber, Alexander N. R. Holmskov, Uffe Moeller, Jesper Bonnet Templeton, Steven P. |
author_facet | Bhattacharya, Shreya Maupin, Alec Jacob Schlosser, Anders Grønnegaard Füchtbauer, Ernst-Martin Gloria, Yamel Cardona Weber, Alexander N. R. Holmskov, Uffe Moeller, Jesper Bonnet Templeton, Steven P. |
author_sort | Bhattacharya, Shreya |
collection | PubMed |
description | Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that binds chitin, is found in human lung epithelium and modulates lung epithelial inflammatory responses to A. fumigatus cell wall polysaccharides. We previously reported the detrimental role of FIBCD1 in a murine model of pulmonary invasive aspergillosis. However, the effect that chitin and chitin-containing A. fumigatus conidia exerts on lung epithelium following exposure through FIBCD1 is not yet fully explored. Using both in vitro and in vivo strategies, we examined how lung and lung epithelial gene expression are modified after exposure to fungal conidia or chitin fragments in the presence or absence of FIBCD1. FIBCD1 expression was associated with a decrease in inflammatory cytokines with increasing size of chitin (dimer-oligomer). Thus, our results demonstrate that FIBCD1 expression modulates cytokine and chemokine expression in response to A. fumigatus conidia that is modified by the presence of chitin particles. |
format | Online Article Text |
id | pubmed-9994688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-99946882023-03-09 The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells Bhattacharya, Shreya Maupin, Alec Jacob Schlosser, Anders Grønnegaard Füchtbauer, Ernst-Martin Gloria, Yamel Cardona Weber, Alexander N. R. Holmskov, Uffe Moeller, Jesper Bonnet Templeton, Steven P. PLoS One Research Article Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that binds chitin, is found in human lung epithelium and modulates lung epithelial inflammatory responses to A. fumigatus cell wall polysaccharides. We previously reported the detrimental role of FIBCD1 in a murine model of pulmonary invasive aspergillosis. However, the effect that chitin and chitin-containing A. fumigatus conidia exerts on lung epithelium following exposure through FIBCD1 is not yet fully explored. Using both in vitro and in vivo strategies, we examined how lung and lung epithelial gene expression are modified after exposure to fungal conidia or chitin fragments in the presence or absence of FIBCD1. FIBCD1 expression was associated with a decrease in inflammatory cytokines with increasing size of chitin (dimer-oligomer). Thus, our results demonstrate that FIBCD1 expression modulates cytokine and chemokine expression in response to A. fumigatus conidia that is modified by the presence of chitin particles. Public Library of Science 2023-03-08 /pmc/articles/PMC9994688/ /pubmed/36888604 http://dx.doi.org/10.1371/journal.pone.0282347 Text en © 2023 Bhattacharya et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bhattacharya, Shreya Maupin, Alec Jacob Schlosser, Anders Grønnegaard Füchtbauer, Ernst-Martin Gloria, Yamel Cardona Weber, Alexander N. R. Holmskov, Uffe Moeller, Jesper Bonnet Templeton, Steven P. The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells |
title | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells |
title_full | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells |
title_fullStr | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells |
title_full_unstemmed | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells |
title_short | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells |
title_sort | role of fibcd1 in response to aspergillus fumigatus in lung epithelial cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994688/ https://www.ncbi.nlm.nih.gov/pubmed/36888604 http://dx.doi.org/10.1371/journal.pone.0282347 |
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