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The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells

Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that...

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Autores principales: Bhattacharya, Shreya, Maupin, Alec Jacob, Schlosser, Anders Grønnegaard, Füchtbauer, Ernst-Martin, Gloria, Yamel Cardona, Weber, Alexander N. R., Holmskov, Uffe, Moeller, Jesper Bonnet, Templeton, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994688/
https://www.ncbi.nlm.nih.gov/pubmed/36888604
http://dx.doi.org/10.1371/journal.pone.0282347
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author Bhattacharya, Shreya
Maupin, Alec Jacob
Schlosser, Anders Grønnegaard
Füchtbauer, Ernst-Martin
Gloria, Yamel Cardona
Weber, Alexander N. R.
Holmskov, Uffe
Moeller, Jesper Bonnet
Templeton, Steven P.
author_facet Bhattacharya, Shreya
Maupin, Alec Jacob
Schlosser, Anders Grønnegaard
Füchtbauer, Ernst-Martin
Gloria, Yamel Cardona
Weber, Alexander N. R.
Holmskov, Uffe
Moeller, Jesper Bonnet
Templeton, Steven P.
author_sort Bhattacharya, Shreya
collection PubMed
description Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that binds chitin, is found in human lung epithelium and modulates lung epithelial inflammatory responses to A. fumigatus cell wall polysaccharides. We previously reported the detrimental role of FIBCD1 in a murine model of pulmonary invasive aspergillosis. However, the effect that chitin and chitin-containing A. fumigatus conidia exerts on lung epithelium following exposure through FIBCD1 is not yet fully explored. Using both in vitro and in vivo strategies, we examined how lung and lung epithelial gene expression are modified after exposure to fungal conidia or chitin fragments in the presence or absence of FIBCD1. FIBCD1 expression was associated with a decrease in inflammatory cytokines with increasing size of chitin (dimer-oligomer). Thus, our results demonstrate that FIBCD1 expression modulates cytokine and chemokine expression in response to A. fumigatus conidia that is modified by the presence of chitin particles.
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spelling pubmed-99946882023-03-09 The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells Bhattacharya, Shreya Maupin, Alec Jacob Schlosser, Anders Grønnegaard Füchtbauer, Ernst-Martin Gloria, Yamel Cardona Weber, Alexander N. R. Holmskov, Uffe Moeller, Jesper Bonnet Templeton, Steven P. PLoS One Research Article Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that binds chitin, is found in human lung epithelium and modulates lung epithelial inflammatory responses to A. fumigatus cell wall polysaccharides. We previously reported the detrimental role of FIBCD1 in a murine model of pulmonary invasive aspergillosis. However, the effect that chitin and chitin-containing A. fumigatus conidia exerts on lung epithelium following exposure through FIBCD1 is not yet fully explored. Using both in vitro and in vivo strategies, we examined how lung and lung epithelial gene expression are modified after exposure to fungal conidia or chitin fragments in the presence or absence of FIBCD1. FIBCD1 expression was associated with a decrease in inflammatory cytokines with increasing size of chitin (dimer-oligomer). Thus, our results demonstrate that FIBCD1 expression modulates cytokine and chemokine expression in response to A. fumigatus conidia that is modified by the presence of chitin particles. Public Library of Science 2023-03-08 /pmc/articles/PMC9994688/ /pubmed/36888604 http://dx.doi.org/10.1371/journal.pone.0282347 Text en © 2023 Bhattacharya et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bhattacharya, Shreya
Maupin, Alec Jacob
Schlosser, Anders Grønnegaard
Füchtbauer, Ernst-Martin
Gloria, Yamel Cardona
Weber, Alexander N. R.
Holmskov, Uffe
Moeller, Jesper Bonnet
Templeton, Steven P.
The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells
title The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells
title_full The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells
title_fullStr The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells
title_full_unstemmed The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells
title_short The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells
title_sort role of fibcd1 in response to aspergillus fumigatus in lung epithelial cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994688/
https://www.ncbi.nlm.nih.gov/pubmed/36888604
http://dx.doi.org/10.1371/journal.pone.0282347
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