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The epigenetic legacy of ICU feeding and its consequences
Many critically ill patients face physical, mental or neurocognitive impairments up to years later, the etiology remaining largely unexplained. Aberrant epigenetic changes have been linked to abnormal development and diseases resulting from adverse environmental exposures like major stress or inadeq...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994844/ https://www.ncbi.nlm.nih.gov/pubmed/36794929 http://dx.doi.org/10.1097/MCC.0000000000001021 |
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author | Vanhorebeek, Ilse Van den Berghe, Greet |
author_facet | Vanhorebeek, Ilse Van den Berghe, Greet |
author_sort | Vanhorebeek, Ilse |
collection | PubMed |
description | Many critically ill patients face physical, mental or neurocognitive impairments up to years later, the etiology remaining largely unexplained. Aberrant epigenetic changes have been linked to abnormal development and diseases resulting from adverse environmental exposures like major stress or inadequate nutrition. Theoretically, severe stress and artificial nutritional management of critical illness thus could induce epigenetic changes explaining long-term problems. We review supporting evidence. RECENT FINDINGS: Epigenetic abnormalities are found in various critical illness types, affecting DNA-methylation, histone-modification and noncoding RNAs. They at least partly arise de novo after ICU-admission. Many affect genes with functions relevant for and several associate with long-term impairments. As such, de novo DNA-methylation changes in critically ill children statistically explained part of their disturbed long-term physical/neurocognitive development. These methylation changes were in part evoked by early-parenteral-nutrition (early-PN) and statistically explained harm by early-PN on long-term neurocognitive development. Finally, long-term epigenetic abnormalities beyond hospital-discharge have been identified, affecting pathways highly relevant for long-term outcomes. SUMMARY: Epigenetic abnormalities induced by critical illness or its nutritional management provide a plausible molecular basis for their adverse effects on long-term outcomes. Identifying treatments to further attenuate these abnormalities opens perspectives to reduce the debilitating legacy of critical illness. |
format | Online Article Text |
id | pubmed-9994844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-99948442023-03-09 The epigenetic legacy of ICU feeding and its consequences Vanhorebeek, Ilse Van den Berghe, Greet Curr Opin Crit Care GASTROINTESTINAL SYSTEM: Edited by Joost Wiersinga Many critically ill patients face physical, mental or neurocognitive impairments up to years later, the etiology remaining largely unexplained. Aberrant epigenetic changes have been linked to abnormal development and diseases resulting from adverse environmental exposures like major stress or inadequate nutrition. Theoretically, severe stress and artificial nutritional management of critical illness thus could induce epigenetic changes explaining long-term problems. We review supporting evidence. RECENT FINDINGS: Epigenetic abnormalities are found in various critical illness types, affecting DNA-methylation, histone-modification and noncoding RNAs. They at least partly arise de novo after ICU-admission. Many affect genes with functions relevant for and several associate with long-term impairments. As such, de novo DNA-methylation changes in critically ill children statistically explained part of their disturbed long-term physical/neurocognitive development. These methylation changes were in part evoked by early-parenteral-nutrition (early-PN) and statistically explained harm by early-PN on long-term neurocognitive development. Finally, long-term epigenetic abnormalities beyond hospital-discharge have been identified, affecting pathways highly relevant for long-term outcomes. SUMMARY: Epigenetic abnormalities induced by critical illness or its nutritional management provide a plausible molecular basis for their adverse effects on long-term outcomes. Identifying treatments to further attenuate these abnormalities opens perspectives to reduce the debilitating legacy of critical illness. Lippincott Williams & Wilkins 2023-04 2023-02-15 /pmc/articles/PMC9994844/ /pubmed/36794929 http://dx.doi.org/10.1097/MCC.0000000000001021 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | GASTROINTESTINAL SYSTEM: Edited by Joost Wiersinga Vanhorebeek, Ilse Van den Berghe, Greet The epigenetic legacy of ICU feeding and its consequences |
title | The epigenetic legacy of ICU feeding and its consequences |
title_full | The epigenetic legacy of ICU feeding and its consequences |
title_fullStr | The epigenetic legacy of ICU feeding and its consequences |
title_full_unstemmed | The epigenetic legacy of ICU feeding and its consequences |
title_short | The epigenetic legacy of ICU feeding and its consequences |
title_sort | epigenetic legacy of icu feeding and its consequences |
topic | GASTROINTESTINAL SYSTEM: Edited by Joost Wiersinga |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994844/ https://www.ncbi.nlm.nih.gov/pubmed/36794929 http://dx.doi.org/10.1097/MCC.0000000000001021 |
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