Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition

Hematopoietic stem and progenitor cells (HSPCs) sustain lifelong hematopoiesis. Mutations of pre-mRNA splicing machinery, especially splicing factor 3b, subunit 1 (SF3B1), are early lesions found in malignancies arising from HSPC dysfunction. However, why splicing factor deficits contribute to HSPC...

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Detalles Bibliográficos
Autores principales: Potts, Kathryn S., Cameron, Rosannah C., Metidji, Amina, Ghazale, Noura, Wallace, LaShanale, Leal-Cervantes, Ana I., Palumbo, Reid, Barajas, Juan Martin, Gupta, Varun, Aluri, Srinivas, Pradhan, Kith, Myers, Jacquelyn A., McKinstry, Mia, Bai, Xiaoying, Choudhary, Gaurav S., Shastri, Aditi, Verma, Amit, Obeng, Esther A., Bowman, Teresa V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994853/
https://www.ncbi.nlm.nih.gov/pubmed/36516770
http://dx.doi.org/10.1016/j.celrep.2022.111825

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