Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration

Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months old) and demonstrate that in comparison to young mice, one-third of old...

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Detalles Bibliográficos
Autores principales: Ritzel, Rodney M., Li, Yun, Jiao, Yun, Lei, Zhuofan, Doran, Sarah J., He, Junyun, Shahror, Rami A., Henry, Rebecca J., Khan, Romeesa, Tan, Chunfeng, Liu, Shaolin, Stoica, Bogdan A., Faden, Alan I., Szeto, Gregory, Loane, David J., Wu, Junfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995070/
https://www.ncbi.nlm.nih.gov/pubmed/36888713
http://dx.doi.org/10.1126/sciadv.add1101

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