Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C

The polymerase-associated factor 1 complex (PAF1C) is a key, post-initiation transcriptional regulator of both promoter-proximal pausing and productive elongation catalyzed by RNA Pol II and is also involved in transcriptional repression of viral gene expression during human immunodeficiency virus–1...

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Detalles Bibliográficos
Autores principales: Soliman, Shimaa H. A., Cisneros, William J., Iwanaszko, Marta, Aoi, Yuki, Ganesan, Sheetal, Walter, Miriam, Zeidner, Jacob M., Mishra, Rama K., Kim, Eun-Young, Wolinsky, Steven M., Hultquist, Judd F., Shilatifard, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995073/
https://www.ncbi.nlm.nih.gov/pubmed/36888719
http://dx.doi.org/10.1126/sciadv.adf2468

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