Predictive factors of quality of life in chronic pruritus patients: A cross-sectional study

BACKGROUND: Chronic pruritus severely impacts the quality of life (QoL) of patients. Due to its multifactorial nature, the presence of factors that can predict itch-specific QoL needs comprehensive exploration. OBJECTIVE: To determine the sociodemographic and itch-related factors that predict itch-specific QoL among patients suffering from chronic pruritus. METHODS: We conducted a cross-sectional study on a cohort of patients with chronic pruritus at our itch clinic in Miami, Florida from 2016 to 2022 and explored predictors of itch-specific QoL using simple and multivariable linear regression models. RESULTS: Sociodemographic factors that had a negative impact on itch-specific QoL included female sex and multiracial ethnicity. The main itch-related factors that were associated with a negative impact on itch-specific QoL included pruritus in the upper extremity and buttocks/genital regions and associated factors such as pain, cold sensation, sweating, and stress. LIMITATIONS: Single-center study at a tertiary care center with a primarily non-Hispanic White population and use of self-administered questionnaires. CONCLUSIONS: A variety of factors help predict the itch-specific QoL in patients with chronic pruritus. Understanding these factors can help clinicians evaluate and treat patients suffering from chronic itch.