Cargando…

Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia

Acute myeloid leukemia may be characterized by a fraction of leukemia stem cells (LSCs) that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs to early therapy resistance and AML regeneration remains controversial. We prospectively identify LSCs in AML patients...

Descripción completa

Detalles Bibliográficos
Autores principales:	Naldini, Matteo Maria, Casirati, Gabriele, Barcella, Matteo, Rancoita, Paola Maria Vittoria, Cosentino, Andrea, Caserta, Carolina, Pavesi, Francesca, Zonari, Erika, Desantis, Giacomo, Gilioli, Diego, Carrabba, Matteo Giovanni, Vago, Luca, Bernardi, Massimo, Di Micco, Raffaella, Di Serio, Clelia, Merelli, Ivan, Volpin, Monica, Montini, Eugenio, Ciceri, Fabio, Gentner, Bernhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995364/ https://www.ncbi.nlm.nih.gov/pubmed/36890137 http://dx.doi.org/10.1038/s41467-023-36969-0

Ejemplares similares

P436: CUTTING-EDGE TRANSCRIPTOMICS TO IDENTIFY LEUKEMIA-INTRINSIC AND -EXTRINSIC CORRELATES OF IMMUNE ESCAPE AND POST-TRANSPLANTATION RELAPSE
por: Edoardo Rovatti, Pier, et al.
Publicado: (2023)

Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses
por: Mucci, Adele, et al.
Publicado: (2021)

P1373: UNCOVERING UPSIDES AND PITFALLS OF BASE AND PRIME EDITING IN HEMATOPOIETIC STEM CELLS
por: Fiumara, Martina, et al.
Publicado: (2023)

MRD in Venetoclax-Based Treatment for AML: Does it Really Matter?
por: Bernardi, Massimo, et al.
Publicado: (2022)

P429: THERAPY-INDUCED SENESCENCE TRIGGERS UPREGULATION OF ANTIGEN PRESENTATION VIA PRC2 INHIBITION AND PROMOTES ANTI-TUMOUR IMMUNITY IN ACUTE MYELOID LEUKAEMIA
por: Gilioli, Diego, et al.
Publicado: (2023)

Integrated Multiomic Profiling Identifies the Epigenetic Regulator PRC2 as a Therapeutic Target to Counteract Leukemia Immune Escape and Relapse
por: Gambacorta, Valentina, et al.
Publicado: (2022)

Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy
por: Zonari, Erika, et al.
Publicado: (2017)

S250: UNVEILING THE BIOLOGICAL ROLE OF PERIPHERAL BLOOD HUMAN CIRCULATING HEMATOPOIETIC STEM AND PROGENITOR CELLS
por: Quaranta, Pamela, et al.
Publicado: (2023)

CLRM-08 TARGETING IMMUNE-PAYLOAD TO THE GLIOBLASTOMA TUMOR MICROENVIRONMENT USING A MACROPHAGE-BASED TREATMENT RELYING ON AUTOLOGOUS, GENETICALLY MODIFIED, HEMATOPOIETIC STEM CELL-BASED THERAPY: THE TEM-GBM STUDY (NCT03866109)
por: Eoli, Marica, et al.
Publicado: (2022)

Integrating a prospective pilot trial and patient-derived xenografts to trace metabolic changes associated with acute myeloid leukemia
por: Carrabba, Matteo G., et al.
Publicado: (2016)

Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy
por: Jofra Hernández, Raisa, et al.
Publicado: (2021)

Nanosphere's Verigene(®) Blood Culture Assay to Detect Multidrug-Resistant Gram-Negative Bacterial Outbreak: A Prospective Study on 79 Hematological Patients in a Country with High Prevalence of Antimicrobial Resistance
por: Greco, Raffaella, et al.
Publicado: (2019)

Expanded circulating hematopoietic stem/ progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis
por: Capo, Valentina, et al.
Publicado: (2020)

Following-up allogeneic transplantation recipients during the COVID-19 pandemic
por: Lupo-Stanghellini, Maria Teresa, et al.
Publicado: (2020)

Technical Differences over the Course of the Match: An Analysis of Three Elite Teams in the UEFA Champions League
por: Magni, Marco, et al.
Publicado: (2023)

Validating the Italian Version of the Disgust and Propensity Scale-Revised
por: Martoni, Riccardo M., et al.
Publicado: (2017)

P1359: USING GENE-MODIFIED AUTOLOGOUS STEM CELLS PROGENY TO REEDUCATE THE TUMOR IMMUNE MICROENVIRONMENT OF SOLID TUMORS (TEM-GBM STUDY)
por: Farina, F., et al.
Publicado: (2022)

PB2426: SORAFENIB MAINTENANCE TAILORED TO FLT3-MUTATED AML AFTER ALLOGENEIC HCT IS HIGHLY FEASIBLE AND EFFECTIVE: A REAL-LIFE EXPERIENCE
por: Diral, Elisa, et al.
Publicado: (2023)

The transcription factor HIF2α partakes in the differentiation block of acute myeloid leukemia
por: Magliulo, Daniela, et al.
Publicado: (2023)

Cystic Fibrosis Defective Response to Infection Involves Autophagy and Lipid Metabolism
por: Mingione, Alessandra, et al.
Publicado: (2020)

P1638: CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL (CHIP) IS A RISK FACTOR FOR PULMONARY VASCULAR THROMBOSIS IN PATIENTS WITH COVID-19.
por: Aletti, Federico Mario, et al.
Publicado: (2023)

New antibiotics for bad bugs: where are we?
por: Bassetti, Matteo, et al.
Publicado: (2013)

S255: CELLULAR SENESCENCE AND INFLAMMATORY PROGRAMS ARE UNINTENDED CONSEQUENCES OF CRISPR-CAS9 GENE EDITING IN HEMATOPOIETIC STEM AND PROGENITOR CELLS
por: Conti, Anastasia, et al.
Publicado: (2023)

Evaluation of Quality Assessment Protocols for High Throughput Genome Resequencing Data
por: Chiara, Matteo, et al.
Publicado: (2017)

Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
por: Escobar, Giulia, et al.
Publicado: (2014)

Azacitidine and donor lymphocytes infusions in acute myeloid leukemia and myelodysplastic syndrome relapsed after allogeneic hematopoietic stem cell transplantation from alternative donors
por: Liberatore, Carmine, et al.
Publicado: (2022)

Use of a maturity model for facilitating the introduction of CAR T-cell therapy—Results of the START CAR-T project
por: Bramanti, Stefania, et al.
Publicado: (2022)

Enteric Microbiome Markers as Early Predictors of Clinical Outcome in Allogeneic Hematopoietic Stem Cell Transplant: Results of a Prospective Study in Adult Patients
por: Mancini, Nicasio, et al.
Publicado: (2017)

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response
por: Schiroli, Giulia, et al.
Publicado: (2019)

From Immunotoxins to Suicide Toxin Delivery Approaches: Is There a Clinical Opportunity?
por: Ardini, Matteo, et al.
Publicado: (2022)

Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings
por: Petrillo, Carolina, et al.
Publicado: (2019)

Dynamic Activity of miR-125b and miR-93 during Murine Neural Stem Cell Differentiation In Vitro and in the Subventricular Zone Neurogenic Niche
por: Lattanzi, Annalisa, et al.
Publicado: (2013)

A novel scan statistics approach for clustering identification and comparison in binary genomic data
por: Pellin, Danilo, et al.
Publicado: (2016)

Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency
por: Barzaghi, Federica, et al.
Publicado: (2022)

Morphological and Chemical Traits of Cladonia Respond to Multiple Environmental Factors in Acidic Dry Grasslands
por: Gheza, Gabriele, et al.
Publicado: (2021)

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
por: Biavasco, Riccardo, et al.
Publicado: (2021)

The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy
por: Naldini, Luigi, et al.
Publicado: (2022)

The prospects for the SARS‐CoV‐2 pandemic in Africa
por: Quaresima, Virginia, et al.
Publicado: (2020)

Topolnogical classifier for detecting the emergence of epileptic seizures
por: Piangerelli, Marco, et al.
Publicado: (2018)

Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress
por: Montaldo, Elisa, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vnkpscnu4tl24g85383utpff4q