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Unmet needs in ANCA-associated vasculitis: Physicians’ and patients’ perspectives

In recent years, clinical research has increased significantly and therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis have improved. However, there are still unanswered questions and unmet needs about AAV patients. The purpose of this review is to examine the frontiers of...

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Autores principales: Quartuccio, Luca, Treppo, Elena, Urso, Livio, Del Frate, Giulia, Mescia, Federica, Alberici, Federico, Vaglio, Augusto, Emmi, Giacomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995379/
https://www.ncbi.nlm.nih.gov/pubmed/36911748
http://dx.doi.org/10.3389/fimmu.2023.1112899
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author Quartuccio, Luca
Treppo, Elena
Urso, Livio
Del Frate, Giulia
Mescia, Federica
Alberici, Federico
Vaglio, Augusto
Emmi, Giacomo
author_facet Quartuccio, Luca
Treppo, Elena
Urso, Livio
Del Frate, Giulia
Mescia, Federica
Alberici, Federico
Vaglio, Augusto
Emmi, Giacomo
author_sort Quartuccio, Luca
collection PubMed
description In recent years, clinical research has increased significantly and therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis have improved. However, there are still unanswered questions and unmet needs about AAV patients. The purpose of this review is to examine the frontiers of research related to emerging biomarkers eventually predicting relapse, and new therapeutic approaches, not to mention new quality of life assessment tools. Identifying predictors of relapse may help optimize therapeutic strategies, minimize disease recurrence, and reduce treatment-related side effects. In addition, it is important to recognize that patients may suffer long-term consequences of the disease and its treatment, which, although life-saving, is often associated with significant side effects. Our goal, therefore, is to highlight what has been achieved, the pitfalls, and what still needs to be done, comparing the views of physicians and patients.
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spelling pubmed-99953792023-03-10 Unmet needs in ANCA-associated vasculitis: Physicians’ and patients’ perspectives Quartuccio, Luca Treppo, Elena Urso, Livio Del Frate, Giulia Mescia, Federica Alberici, Federico Vaglio, Augusto Emmi, Giacomo Front Immunol Immunology In recent years, clinical research has increased significantly and therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis have improved. However, there are still unanswered questions and unmet needs about AAV patients. The purpose of this review is to examine the frontiers of research related to emerging biomarkers eventually predicting relapse, and new therapeutic approaches, not to mention new quality of life assessment tools. Identifying predictors of relapse may help optimize therapeutic strategies, minimize disease recurrence, and reduce treatment-related side effects. In addition, it is important to recognize that patients may suffer long-term consequences of the disease and its treatment, which, although life-saving, is often associated with significant side effects. Our goal, therefore, is to highlight what has been achieved, the pitfalls, and what still needs to be done, comparing the views of physicians and patients. Frontiers Media S.A. 2023-02-23 /pmc/articles/PMC9995379/ /pubmed/36911748 http://dx.doi.org/10.3389/fimmu.2023.1112899 Text en Copyright © 2023 Quartuccio, Treppo, Urso, Del Frate, Mescia, Alberici, Vaglio and Emmi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Quartuccio, Luca
Treppo, Elena
Urso, Livio
Del Frate, Giulia
Mescia, Federica
Alberici, Federico
Vaglio, Augusto
Emmi, Giacomo
Unmet needs in ANCA-associated vasculitis: Physicians’ and patients’ perspectives
title Unmet needs in ANCA-associated vasculitis: Physicians’ and patients’ perspectives
title_full Unmet needs in ANCA-associated vasculitis: Physicians’ and patients’ perspectives
title_fullStr Unmet needs in ANCA-associated vasculitis: Physicians’ and patients’ perspectives
title_full_unstemmed Unmet needs in ANCA-associated vasculitis: Physicians’ and patients’ perspectives
title_short Unmet needs in ANCA-associated vasculitis: Physicians’ and patients’ perspectives
title_sort unmet needs in anca-associated vasculitis: physicians’ and patients’ perspectives
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995379/
https://www.ncbi.nlm.nih.gov/pubmed/36911748
http://dx.doi.org/10.3389/fimmu.2023.1112899
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