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Circadian rhythm in restless legs syndrome

Restless legs syndrome (RLS) is a sensorimotor disorder with a obvious circadian rhythm, as its symptoms often occur or worsen only in the evening or at night. The mechanisms behind the rhythms of RLS have not yet been fully elucidated. This review explores possible causes for the circadian fluctuat...

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Autores principales: Tang, Mingyang, Sun, Qingqing, Zhang, Yanan, Li, Huimin, Wang, Dong, Wang, Ying, Wang, Zan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995399/
https://www.ncbi.nlm.nih.gov/pubmed/36908590
http://dx.doi.org/10.3389/fneur.2023.1105463
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author Tang, Mingyang
Sun, Qingqing
Zhang, Yanan
Li, Huimin
Wang, Dong
Wang, Ying
Wang, Zan
author_facet Tang, Mingyang
Sun, Qingqing
Zhang, Yanan
Li, Huimin
Wang, Dong
Wang, Ying
Wang, Zan
author_sort Tang, Mingyang
collection PubMed
description Restless legs syndrome (RLS) is a sensorimotor disorder with a obvious circadian rhythm, as its symptoms often occur or worsen only in the evening or at night. The mechanisms behind the rhythms of RLS have not yet been fully elucidated. This review explores possible causes for the circadian fluctuations of the symptomatology, including the levels of iron, dopamine, melatonin, melanocortin, and thyroid-stimulating hormone in the brain, as well as conditions such as peripheral hypoxia and microvascular function disorders. The metabolic disturbances of the substances above can create a pathological imbalance, which is further aggravated by physiological fluctuations of circadian rhythms, and results in the worsening of RLS symptoms at night. The review concludes with the suggestions for RLS treatment and research directions in the future.
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spelling pubmed-99953992023-03-10 Circadian rhythm in restless legs syndrome Tang, Mingyang Sun, Qingqing Zhang, Yanan Li, Huimin Wang, Dong Wang, Ying Wang, Zan Front Neurol Neurology Restless legs syndrome (RLS) is a sensorimotor disorder with a obvious circadian rhythm, as its symptoms often occur or worsen only in the evening or at night. The mechanisms behind the rhythms of RLS have not yet been fully elucidated. This review explores possible causes for the circadian fluctuations of the symptomatology, including the levels of iron, dopamine, melatonin, melanocortin, and thyroid-stimulating hormone in the brain, as well as conditions such as peripheral hypoxia and microvascular function disorders. The metabolic disturbances of the substances above can create a pathological imbalance, which is further aggravated by physiological fluctuations of circadian rhythms, and results in the worsening of RLS symptoms at night. The review concludes with the suggestions for RLS treatment and research directions in the future. Frontiers Media S.A. 2023-02-23 /pmc/articles/PMC9995399/ /pubmed/36908590 http://dx.doi.org/10.3389/fneur.2023.1105463 Text en Copyright © 2023 Tang, Sun, Zhang, Li, Wang, Wang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Tang, Mingyang
Sun, Qingqing
Zhang, Yanan
Li, Huimin
Wang, Dong
Wang, Ying
Wang, Zan
Circadian rhythm in restless legs syndrome
title Circadian rhythm in restless legs syndrome
title_full Circadian rhythm in restless legs syndrome
title_fullStr Circadian rhythm in restless legs syndrome
title_full_unstemmed Circadian rhythm in restless legs syndrome
title_short Circadian rhythm in restless legs syndrome
title_sort circadian rhythm in restless legs syndrome
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995399/
https://www.ncbi.nlm.nih.gov/pubmed/36908590
http://dx.doi.org/10.3389/fneur.2023.1105463
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